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• W2139146249 abstract "After the publication of two landmark studies, 1 Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002; 346: 549-556 Crossref PubMed Scopus (4412) Google Scholar , 2 Bernard S.A. Gray T.W. Buist M.D. et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002; 346: 557-563 Crossref PubMed Scopus (4189) Google Scholar mild therapeutic hypothermia (MTH) after cardiac arrest (CA) to improve neurologic outcome found its way to the international resuscitation guidelines and is widely used since then. Several invasive- and non-invasive methods to induce MTH have been tested and some have been successfully implemented. 3 Xiao F. Safar P. Alexander H. Peritoneal cooling for mild cerebral hypothermia after cardiac arrest in dogs. Resuscitation. 1995; 30: 51-59 Abstract Full Text PDF PubMed Scopus (40) Google Scholar , 4 Behringer W. Safar P. Wu X. et al. Veno-venous extracorporeal blood shunt cooling to induce mild hypothermia in dog experiments and review of cooling methods. Resuscitation. 2002; 54: 89-98 Abstract Full Text Full Text PDF PubMed Scopus (36) Google Scholar , 5 Nozari A. Safar P. Stezoski S.W. et al. Critical time window for intra-arrest cooling with cold saline flush in a dog model of cardiopulmonary resuscitation. Circulation. 2006; 113: 2690-2696 Crossref PubMed Scopus (160) Google Scholar , 6 Holzer M. Müllner M. Sterz F. et al. Efficacy and safety of endovascular cooling after cardiac arrest: cohort study and Bayesian approach. Stroke. 2006; 37: 1792-1797 Crossref PubMed Scopus (182) Google Scholar , 7 Haugk M. Sterz F. Grassberger M. et al. Feasibility and efficacy of a new non-invasive surface cooling device in post-resuscitation intensive care medicine. Resuscitation. 2007; 75: 76-81 Abstract Full Text Full Text PDF PubMed Scopus (102) Google Scholar , 8 Kliegel A. Janata A. Wandaller C. et al. Cold infusions alone are effective for induction of therapeutic hypothermia but do not keep patients cool after cardiac arrest. Resuscitation. 2007; 73: 46-53 Abstract Full Text Full Text PDF PubMed Scopus (127) Google Scholar , 9 Uray T. Malzer R. Vienna Hypothermia After Cardiac Arrest (HACA) Study Group Out-of-hospital surface cooling to induce mild hypothermia in human cardiac arrest: a feasibility trial. Resuscitation. 2008; 77: 331-338 Abstract Full Text Full Text PDF PubMed Scopus (72) Google Scholar , 10 Busch H.J. Eichwede F. Födisch M. et al. Safety and feasibility of nasopharyngeal evaporative cooling in the emergency department setting in survivors of cardiac arrest. Resuscitation. 2010; 81: 943-949 Abstract Full Text Full Text PDF PubMed Scopus (63) Google Scholar Although 2 recently published studies 11 Nielsen N. Wetterslev J. Cronberg T. et al. Targeted temperature management at 33 °C versus 36 °C after cardiac arrest. N Engl J Med. 2013; 369: 2197-2206 Crossref PubMed Scopus (1891) Google Scholar , 12 Kim F. Nichol G. Maynard C. et al. Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: a randomized clinical trial. J Am Med Assoc. 2014; 311: 45-52 Crossref PubMed Scopus (452) Google Scholar have raised new controversies concerning efficacy, research still has not come to a final decision to dismiss this therapy. 13 Rittenberger J.C. Callaway C.W. Temperature management and modern post-cardiac arrest care. N Engl J Med. 2013; 369: 2262-2263 Crossref PubMed Scopus (50) Google Scholar Also, in neonatal resuscitation, mild hypothermia is an accepted tool to reduce neuronal damage and improve outcomes. 14 Gluckman P.D. Wyatt J.S. Azzopardi D. et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005; 365: 663-670 Abstract Full Text Full Text PDF PubMed Scopus (1791) Google Scholar , 15 Shankaran S. Laptook A.R. Ehrenkranz R.A. et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005; 353: 1574-1584 Crossref PubMed Scopus (2081) Google Scholar Besides invasive and noninvasive cooling techniques, drug-induced (or so called pharmacological facilitated) hypothermia has been under investigation for a long time. 16 Katz L.M. Young A. Frank J.E. et al. Neurotensin-induced hypothermia improves neurologic outcome after hypoxic-ischemia. Crit Care Med. 2004; 32: 806-810 Crossref PubMed Scopus (64) Google Scholar , 17 Doyle K.P. Suchland K.L. Ciesielski T.M. et al. Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury. Stroke. 2007; 38: 2569-2576 Crossref PubMed Scopus (87) Google Scholar , 18 Sun S. Tang W. Song F. et al. Pharmacologically induced hypothermia with cannabinoid receptor agonist WIN55, 212-2 after cardiopulmonary resuscitation. Crit Care Med. 2010; 38: 2282-2286 Crossref PubMed Scopus (23) Google Scholar , 19 Schneider A. Teschendorf P. Vogel P. et al. Facilitation of hypothermia by quinpirole and 8-OH-DPAT in a rat model of cardiac arrest. Resuscitation. 2012; 83: 232-237 Abstract Full Text Full Text PDF PubMed Scopus (8) Google Scholar This approach might represent an alternative to induce cooling without any need for devices or fluids, since fluids given immediately after restoration of spontaneous circulation (ROSC) may have the possible side effect of causing pulmonary edema and rearrests, as recently described. 12 Kim F. Nichol G. Maynard C. et al. Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: a randomized clinical trial. J Am Med Assoc. 2014; 311: 45-52 Crossref PubMed Scopus (452) Google Scholar The “when and how” and other details of cooling have been an elusive target which remains to be optimized." @default.
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• W2139146249 title "Finding a faster and safer way to “catch a cold” after cardiac arrest: We may be getting closer" @default.
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