FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139160649> ?p ?o ?g. }

• W2139160649 endingPage "H1077" @default.
• W2139160649 startingPage "H1069" @default.
• W2139160649 abstract "Insulin resistance or diabetes is associated with limited exercise capacity, which can be caused by the abnormal energy metabolism in skeletal muscle. Oxidative stress is involved in mitochondrial dysfunction in diabetes. We hypothesized that increased oxidative stress could cause mitochondrial dysfunction in skeletal muscle and make contribution to exercise intolerance in diabetes. C57/BL6J mice were fed on normal diet or high fat diet (HFD) for 8 wk to induce obesity with insulin resistance and diabetes. Treadmill tests with expired gas analysis were performed to determine the exercise capacity and whole body oxygen uptake (V̇o 2 ). The work (vertical distance × body weight) to exhaustion was reduced in the HFD mice by 36%, accompanied by a 16% decrease of peak V̇o 2 . Mitochondrial ADP-stimulated respiration, electron transport chain complex I and III activities, and mitochondrial content in skeletal muscle were decreased in the HFD mice. Furthermore, superoxide production and NAD(P)H oxidase activity in skeletal muscle were significantly increased in the HFD mice. Intriguingly, the treatment of HFD-fed mice with apocynin [10 mmol/l; an inhibitor of NAD(P)H oxidase activation] improved exercise intolerance and mitochondrial dysfunction in skeletal muscle without affecting glucose metabolism itself. The exercise capacity and mitochondrial function in skeletal muscle were impaired in type 2 diabetes, which might be due to enhanced oxidative stress. Therapies designed to regulate oxidative stress and maintain mitochondrial function could be beneficial to improve the exercise capacity in type 2 diabetes." @default.
• W2139160649 created "2016-06-24" @default.
• W2139160649 creator A5007114143 @default.
• W2139160649 creator A5010269285 @default.
• W2139160649 creator A5013900477 @default.
• W2139160649 creator A5015752932 @default.
• W2139160649 creator A5026997098 @default.
• W2139160649 creator A5027418921 @default.
• W2139160649 creator A5032927612 @default.
• W2139160649 creator A5046904303 @default.
• W2139160649 creator A5052204317 @default.
• W2139160649 creator A5052711475 @default.
• W2139160649 creator A5057784648 @default.
• W2139160649 creator A5063576196 @default.
• W2139160649 creator A5068906585 @default.
• W2139160649 creator A5069484729 @default.
• W2139160649 creator A5091849037 @default.
• W2139160649 date "2009-09-01" @default.
• W2139160649 modified "2023-10-15" @default.
• W2139160649 title "Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice" @default.
• W2139160649 cites W1488599994 @default.
• W2139160649 cites W1569716332 @default.
• W2139160649 cites W1867822244 @default.
• W2139160649 cites W1962409919 @default.
• W2139160649 cites W1989150156 @default.
• W2139160649 cites W2016871397 @default.
• W2139160649 cites W2023821775 @default.
• W2139160649 cites W2027670788 @default.
• W2139160649 cites W2036576882 @default.
• W2139160649 cites W2037331996 @default.
• W2139160649 cites W2048220093 @default.
• W2139160649 cites W2057128455 @default.
• W2139160649 cites W2060161793 @default.
• W2139160649 cites W2070745109 @default.
• W2139160649 cites W2072311601 @default.
• W2139160649 cites W2072995989 @default.
• W2139160649 cites W2085429666 @default.
• W2139160649 cites W2087968524 @default.
• W2139160649 cites W2090016088 @default.
• W2139160649 cites W2093366966 @default.
• W2139160649 cites W2093891766 @default.
• W2139160649 cites W2096869450 @default.
• W2139160649 cites W2101175755 @default.
• W2139160649 cites W2110182057 @default.
• W2139160649 cites W2123106337 @default.
• W2139160649 cites W2134498505 @default.
• W2139160649 cites W2143722118 @default.
• W2139160649 cites W2150709092 @default.
• W2139160649 cites W2154768987 @default.
• W2139160649 cites W2155536232 @default.
• W2139160649 cites W2158899004 @default.
• W2139160649 cites W2159581380 @default.
• W2139160649 cites W2164444293 @default.
• W2139160649 cites W2169593539 @default.
• W2139160649 cites W4241696074 @default.
• W2139160649 doi "https://doi.org/10.1152/ajpheart.00267.2009" @default.
• W2139160649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19617406" @default.
• W2139160649 hasPublicationYear "2009" @default.
• W2139160649 type Work @default.
• W2139160649 sameAs 2139160649 @default.
• W2139160649 citedByCount "113" @default.
• W2139160649 countsByYear W21391606492012 @default.
• W2139160649 countsByYear W21391606492013 @default.
• W2139160649 countsByYear W21391606492014 @default.
• W2139160649 countsByYear W21391606492015 @default.
• W2139160649 countsByYear W21391606492016 @default.
• W2139160649 countsByYear W21391606492017 @default.
• W2139160649 countsByYear W21391606492018 @default.
• W2139160649 countsByYear W21391606492019 @default.
• W2139160649 countsByYear W21391606492020 @default.
• W2139160649 countsByYear W21391606492021 @default.
• W2139160649 countsByYear W21391606492022 @default.
• W2139160649 countsByYear W21391606492023 @default.
• W2139160649 crossrefType "journal-article" @default.
• W2139160649 hasAuthorship W2139160649A5007114143 @default.
• W2139160649 hasAuthorship W2139160649A5010269285 @default.
• W2139160649 hasAuthorship W2139160649A5013900477 @default.
• W2139160649 hasAuthorship W2139160649A5015752932 @default.
• W2139160649 hasAuthorship W2139160649A5026997098 @default.
• W2139160649 hasAuthorship W2139160649A5027418921 @default.
• W2139160649 hasAuthorship W2139160649A5032927612 @default.
• W2139160649 hasAuthorship W2139160649A5046904303 @default.
• W2139160649 hasAuthorship W2139160649A5052204317 @default.
• W2139160649 hasAuthorship W2139160649A5052711475 @default.
• W2139160649 hasAuthorship W2139160649A5057784648 @default.
• W2139160649 hasAuthorship W2139160649A5063576196 @default.
• W2139160649 hasAuthorship W2139160649A5068906585 @default.
• W2139160649 hasAuthorship W2139160649A5069484729 @default.
• W2139160649 hasAuthorship W2139160649A5091849037 @default.
• W2139160649 hasConcept C126322002 @default.
• W2139160649 hasConcept C134018914 @default.
• W2139160649 hasConcept C185592680 @default.
• W2139160649 hasConcept C2776151105 @default.
• W2139160649 hasConcept C2777180221 @default.
• W2139160649 hasConcept C2777321227 @default.
• W2139160649 hasConcept C2777391703 @default.
• W2139160649 hasConcept C2778198053 @default.
• W2139160649 hasConcept C2779959927 @default.

• next