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- W2139170332 abstract "Diseases of polyglutamine expansion, Alzheimers disease and Parkinsons disease are neurodegenerative diseases associated with insoluble protein aggregates and neuronal death. These diseases constitute a group of devastating diseases for which there is currently little treatment. The protein aggregates may be the cause of neuronal death, although there is some controversy as to which form of aggregation (oligomers, polymers or microscopic aggregates) is the most toxic. More than a decade ago, the participation of transglutaminases in the formation of the abnormal protein aggregates was proposed. Transglutaminases are a large family of enzymes that catalyze the formation of Nε(γ-glutamyl)-lysine isodipeptide crosslinks between proteins. In this review, we summarize the evidence supporting the participation of transglutaminase in diseases of the central nervous system. We also describe newly developed transglutaminase inhibitors and their potential use as therapeutic agents in neurological disease. Keywords: Polyglutamine, Alzheimer, Parkinson, protein aggregation, neuronal inclusions" @default.
- W2139170332 created "2016-06-24" @default.
- W2139170332 creator A5030843229 @default.
- W2139170332 creator A5044066048 @default.
- W2139170332 creator A5046483200 @default.
- W2139170332 creator A5055372504 @default.
- W2139170332 creator A5057659816 @default.
- W2139170332 date "2010-04-01" @default.
- W2139170332 modified "2023-10-18" @default.
- W2139170332 title "Transglutaminase-Catalyzed Crosslinking in Neurological Disease: From Experimental Evidence to Therapeutic Inhibition" @default.
- W2139170332 cites W126127139 @default.
- W2139170332 cites W1486999320 @default.
- W2139170332 cites W1501599416 @default.
- W2139170332 cites W1503629275 @default.
- W2139170332 cites W1505026345 @default.
- W2139170332 cites W1515840075 @default.
- W2139170332 cites W1522868787 @default.
- W2139170332 cites W1554807651 @default.
- W2139170332 cites W1557266545 @default.
- W2139170332 cites W1560399205 @default.
- W2139170332 cites W1567169100 @default.
- W2139170332 cites W1600271867 @default.
- W2139170332 cites W1622884348 @default.
- W2139170332 cites W164897159 @default.
- W2139170332 cites W1690904680 @default.
- W2139170332 cites W1692886302 @default.
- W2139170332 cites W1892455234 @default.
- W2139170332 cites W1962249623 @default.
- W2139170332 cites W1963849215 @default.
- W2139170332 cites W1964537515 @default.
- W2139170332 cites W1964982691 @default.
- W2139170332 cites W1965813357 @default.
- W2139170332 cites W1965893090 @default.
- W2139170332 cites W1971012945 @default.
- W2139170332 cites W1972262865 @default.
- W2139170332 cites W1974198498 @default.
- W2139170332 cites W1974407647 @default.
- W2139170332 cites W1974686476 @default.
- W2139170332 cites W1975501457 @default.
- W2139170332 cites W1975895031 @default.
- W2139170332 cites W1977201959 @default.
- W2139170332 cites W1977733590 @default.
- W2139170332 cites W1978580506 @default.
- W2139170332 cites W1979213838 @default.
- W2139170332 cites W1983381624 @default.
- W2139170332 cites W1985116046 @default.
- W2139170332 cites W1985474993 @default.
- W2139170332 cites W1986366555 @default.
- W2139170332 cites W1989619236 @default.
- W2139170332 cites W1991615162 @default.
- W2139170332 cites W1995515835 @default.
- W2139170332 cites W1996014020 @default.
- W2139170332 cites W1996457403 @default.
- W2139170332 cites W2000640243 @default.
- W2139170332 cites W2001299005 @default.
- W2139170332 cites W2002559713 @default.
- W2139170332 cites W2003598238 @default.
- W2139170332 cites W2004428615 @default.
- W2139170332 cites W2004916597 @default.
- W2139170332 cites W2005263917 @default.
- W2139170332 cites W2006808229 @default.
- W2139170332 cites W2007508664 @default.
- W2139170332 cites W2009162588 @default.
- W2139170332 cites W2011719576 @default.
- W2139170332 cites W2011838167 @default.
- W2139170332 cites W2012481532 @default.
- W2139170332 cites W2013029120 @default.
- W2139170332 cites W2016053737 @default.
- W2139170332 cites W2017482945 @default.
- W2139170332 cites W2018435290 @default.
- W2139170332 cites W2019012996 @default.
- W2139170332 cites W2019340689 @default.
- W2139170332 cites W2020206460 @default.
- W2139170332 cites W2020207491 @default.
- W2139170332 cites W2020751496 @default.
- W2139170332 cites W2022356764 @default.
- W2139170332 cites W2022608661 @default.
- W2139170332 cites W2022968099 @default.
- W2139170332 cites W2023759912 @default.
- W2139170332 cites W2023908734 @default.
- W2139170332 cites W2026398932 @default.
- W2139170332 cites W2030947586 @default.
- W2139170332 cites W2031964285 @default.
- W2139170332 cites W2032161390 @default.
- W2139170332 cites W2032255653 @default.
- W2139170332 cites W2033398756 @default.
- W2139170332 cites W2033458389 @default.
- W2139170332 cites W2033842434 @default.
- W2139170332 cites W2034696203 @default.
- W2139170332 cites W2034729641 @default.
- W2139170332 cites W2036603824 @default.
- W2139170332 cites W2036762521 @default.
- W2139170332 cites W2036966579 @default.
- W2139170332 cites W2037877241 @default.
- W2139170332 cites W2038610378 @default.
- W2139170332 cites W2040360751 @default.
- W2139170332 cites W2040618621 @default.
- W2139170332 cites W2042716629 @default.