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• W2139179189 abstract "Abstract c-IAP1 and c-IAP2 are ubiquitin protein ligases (E3s) that repress noncanonical NF-κB activation. We have created mice that bear a mutation in c-IAP2 that inactivates its E3 activity and interferes, in a dominant-negative fashion, with c-IAP1 E3 activity (c-IAP2H570A). The immune response of these animals was explored by infecting them with the Th1-inducing parasite Toxoplasma gondii. Surprisingly, c-IAP2H570A mice succumbed because of T cell production of high levels of proinflammatory cytokines. Unlike naive wild-type (WT) cells, which require signals generated by the TCR and costimulatory receptors to become fully activated, naive c-IAP2H570A T cells proliferated and produced high levels of IL-2 and IFN-γ to stimulation via TCR alone. c-IAP2H570A T cells had constitutive noncanonical NF-κB activation, and IκB kinase inhibition reduced their proliferation to anti-TCR alone to WT levels but had no effect when costimulation via CD28 was provided. Notably, T cells from nfkb2−/− mice, which cannot generate the p52 component of noncanonical NF-κB, were also costimulation independent, consistent with the negative role of this unprocessed protein in canonical NF-κB activation. Whereas T cells from nfkb2+/− mice behaved like WT, coexpression of a single copy of c-IAP2H570A resulted in cleavage of p100, upregulation of p52, and T cell costimulation independence. Thus, p100 represses and p52 promotes costimulation, and the ratio regulates T cell dependence on costimulatory signals." @default.
• W2139179189 created "2016-06-24" @default.
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• W2139179189 date "2013-01-15" @default.
• W2139179189 modified "2023-10-10" @default.
• W2139179189 title "Balance between NF-κB p100 and p52 Regulates T Cell Costimulation Dependence" @default.
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• W2139179189 doi "https://doi.org/10.4049/jimmunol.1201697" @default.
• W2139179189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3538904" @default.
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