FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139179966> ?p ?o ?g. }

• W2139179966 endingPage "E1520" @default.
• W2139179966 startingPage "E1512" @default.
• W2139179966 abstract "Deficient leptin signaling causes infertility via reduced activity of GnRH neurons, causing a hypogonadal state in both rodents and humans. Because GnRH neurons do not express leptin receptors, leptin's effect on GnRH neurons must be indirect. Neurons within the hypothalamic arcuate nucleus that coexpress AGRP and NPY are considered to be important intermediate neurons involved in leptin regulation of GnRH neurons. Previously, we reported that the absence of AGRP and haploinsufficiency of MC4R in leptin receptor mutant ( Lepr db/db ) females result in restoration of fertility and lactation despite the persistence of obesity and insulin resistance. The overarching hypothesis in the present study is that the absence or reduction of leptin's inhibition of AGRP/NPY neurons leads to suppression of GnRH release in cases of leptin signaling deficiency. Since TAC2 (NKB)-TAC3R signaling plays a role in puberty maturation and is modulated by metabolic status, the other aim of this study is to test whether TAC2/NKB neurons in ARC regulated by melanocortinergic signals herein affect leptin's action on puberty and reproduction. Our data showed that AGRP deficiency in Lepr db/db females restores normal timing of vaginal opening and estrous cycling, although uterine weight gain and mammary gland development are morphologically delayed. Nonetheless, Agrp −/− Lepr db/db females are fertile and sustain adequate nutrition of pups with lactation to weaning age. AGRP deficiency results in advanced vaginal opening in wild-type female mice. The postpubertal increase in hypothalamic TAC2 mRNA was not observed in Lepr db/db females, whereas AGRP deficiency restored it in Lepr db/ db females. Additionally, MC4R activation with MTII induced FOS expression in TAC2 neurons, supporting the concept of melanocortinergic regulation of TAC2 neurons. These studies suggest that AGRP imposes an inhibitory effect on puberty and that TAC2 neurons may transmit melanocortinergic inhibition of GnRH neurons." @default.
• W2139179966 created "2016-06-24" @default.
• W2139179966 creator A5002466884 @default.
• W2139179966 creator A5044102386 @default.
• W2139179966 creator A5049019026 @default.
• W2139179966 creator A5050883143 @default.
• W2139179966 creator A5066893639 @default.
• W2139179966 creator A5080117526 @default.
• W2139179966 date "2013-12-15" @default.
• W2139179966 modified "2023-09-25" @default.
• W2139179966 title "Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction" @default.
• W2139179966 cites W1507740248 @default.
• W2139179966 cites W1512733937 @default.
• W2139179966 cites W1967578015 @default.
• W2139179966 cites W1967710144 @default.
• W2139179966 cites W1987711524 @default.
• W2139179966 cites W1989917638 @default.
• W2139179966 cites W1994545264 @default.
• W2139179966 cites W2000858697 @default.
• W2139179966 cites W2005121205 @default.
• W2139179966 cites W2007013969 @default.
• W2139179966 cites W2013780942 @default.
• W2139179966 cites W2020053653 @default.
• W2139179966 cites W2022586856 @default.
• W2139179966 cites W2025295789 @default.
• W2139179966 cites W2030183538 @default.
• W2139179966 cites W2048438803 @default.
• W2139179966 cites W2051192888 @default.
• W2139179966 cites W2053608443 @default.
• W2139179966 cites W2061076565 @default.
• W2139179966 cites W2066904572 @default.
• W2139179966 cites W2069137752 @default.
• W2139179966 cites W2080508995 @default.
• W2139179966 cites W2082925844 @default.
• W2139179966 cites W2090113277 @default.
• W2139179966 cites W2092103308 @default.
• W2139179966 cites W2095692745 @default.
• W2139179966 cites W2103925135 @default.
• W2139179966 cites W2105470099 @default.
• W2139179966 cites W2107277218 @default.
• W2139179966 cites W2108743642 @default.
• W2139179966 cites W2110983908 @default.
• W2139179966 cites W2111571951 @default.
• W2139179966 cites W2125312207 @default.
• W2139179966 cites W2128193301 @default.
• W2139179966 cites W2129281059 @default.
• W2139179966 cites W2130828561 @default.
• W2139179966 cites W2134794678 @default.
• W2139179966 cites W2144690367 @default.
• W2139179966 cites W2167528859 @default.
• W2139179966 cites W2170438345 @default.
• W2139179966 cites W2319361543 @default.
• W2139179966 doi "https://doi.org/10.1152/ajpendo.00241.2013" @default.
• W2139179966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3882375" @default.
• W2139179966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24169048" @default.
• W2139179966 hasPublicationYear "2013" @default.
• W2139179966 type Work @default.
• W2139179966 sameAs 2139179966 @default.
• W2139179966 citedByCount "56" @default.
• W2139179966 countsByYear W21391799662014 @default.
• W2139179966 countsByYear W21391799662015 @default.
• W2139179966 countsByYear W21391799662016 @default.
• W2139179966 countsByYear W21391799662017 @default.
• W2139179966 countsByYear W21391799662018 @default.
• W2139179966 countsByYear W21391799662019 @default.
• W2139179966 countsByYear W21391799662020 @default.
• W2139179966 countsByYear W21391799662021 @default.
• W2139179966 countsByYear W21391799662022 @default.
• W2139179966 countsByYear W21391799662023 @default.
• W2139179966 crossrefType "journal-article" @default.
• W2139179966 hasAuthorship W2139179966A5002466884 @default.
• W2139179966 hasAuthorship W2139179966A5044102386 @default.
• W2139179966 hasAuthorship W2139179966A5049019026 @default.
• W2139179966 hasAuthorship W2139179966A5050883143 @default.
• W2139179966 hasAuthorship W2139179966A5066893639 @default.
• W2139179966 hasAuthorship W2139179966A5080117526 @default.
• W2139179966 hasBestOaLocation W21391799662 @default.
• W2139179966 hasConcept C112672928 @default.
• W2139179966 hasConcept C126322002 @default.
• W2139179966 hasConcept C134018914 @default.
• W2139179966 hasConcept C14372207 @default.
• W2139179966 hasConcept C170493617 @default.
• W2139179966 hasConcept C1998276 @default.
• W2139179966 hasConcept C2776354409 @default.
• W2139179966 hasConcept C2776659692 @default.
• W2139179966 hasConcept C2776808119 @default.
• W2139179966 hasConcept C2777003273 @default.
• W2139179966 hasConcept C2778458369 @default.
• W2139179966 hasConcept C2779234561 @default.
• W2139179966 hasConcept C2780613262 @default.
• W2139179966 hasConcept C511355011 @default.
• W2139179966 hasConcept C54355233 @default.
• W2139179966 hasConcept C71315377 @default.
• W2139179966 hasConcept C71924100 @default.
• W2139179966 hasConcept C86803240 @default.
• W2139179966 hasConceptScore W2139179966C112672928 @default.
• W2139179966 hasConceptScore W2139179966C126322002 @default.
• W2139179966 hasConceptScore W2139179966C134018914 @default.

• next