FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139188448> ?p ?o ?g. }

• W2139188448 endingPage "44825" @default.
• W2139188448 startingPage "44817" @default.
• W2139188448 abstract "Cells may sense heat shock via the accumulation of thermally misfolded proteins. To explore this possibility, we determined the effect of protein misfolding on gene expression in the absence of temperature changes. The imino acid analog azetidine-2-carboxylic acid (AZC) is incorporated into protein competitively with proline and causes reduced thermal stability or misfolding. We found that adding AZC to yeast at sublethal concentrations sufficient to arrest proliferation selectively induced expression of heat shock factor-regulated genes to a maximum of 27-fold and that these inductions were dependent on heat shock factor. AZC treatment also selectively repressed expression of the ribosomal protein genes, another heat shock factor-dependent process, to a maximum of 20-fold. AZC treatment thus strongly and selectively activates heat shock factor. AZC treatment causes this activation by misfolding proteins. Induction of HSP42 by AZC treatment required protein synthesis; treatment with ethanol, which can also misfold proteins, activated heat shock factor, but treatment with canavanine, an arginine analog less potent than AZC at misfolding proteins, did not. However, misfolded proteins did not strongly induce the stress response element regulon. We conclude that misfolded proteins are competent to specifically trigger activation of heat shock factor in response to heat shock." @default.
• W2139188448 created "2016-06-24" @default.
• W2139188448 creator A5007934367 @default.
• W2139188448 creator A5023228042 @default.
• W2139188448 creator A5042850506 @default.
• W2139188448 creator A5053792416 @default.
• W2139188448 creator A5077542898 @default.
• W2139188448 creator A5084616489 @default.
• W2139188448 date "2002-11-01" @default.
• W2139188448 modified "2023-09-29" @default.
• W2139188448 title "Misfolded Proteins Are Competent to Mediate a Subset of the Responses to Heat Shock in Saccharomyces cerevisiae" @default.
• W2139188448 cites W1580242513 @default.
• W2139188448 cites W1614347411 @default.
• W2139188448 cites W1616900398 @default.
• W2139188448 cites W1838616807 @default.
• W2139188448 cites W1970353480 @default.
• W2139188448 cites W2004422661 @default.
• W2139188448 cites W2017619665 @default.
• W2139188448 cites W2023933641 @default.
• W2139188448 cites W2037992536 @default.
• W2139188448 cites W2040518083 @default.
• W2139188448 cites W2043038579 @default.
• W2139188448 cites W2051443873 @default.
• W2139188448 cites W2057813637 @default.
• W2139188448 cites W2064412858 @default.
• W2139188448 cites W2065220166 @default.
• W2139188448 cites W2067708969 @default.
• W2139188448 cites W2068413127 @default.
• W2139188448 cites W2073586734 @default.
• W2139188448 cites W2074828464 @default.
• W2139188448 cites W2082205973 @default.
• W2139188448 cites W2104775769 @default.
• W2139188448 cites W2113836064 @default.
• W2139188448 cites W2121018790 @default.
• W2139188448 cites W2124728054 @default.
• W2139188448 cites W2126415488 @default.
• W2139188448 cites W2148573587 @default.
• W2139188448 cites W2150926065 @default.
• W2139188448 cites W2151697744 @default.
• W2139188448 cites W2153357341 @default.
• W2139188448 doi "https://doi.org/10.1074/jbc.m204686200" @default.
• W2139188448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12239211" @default.
• W2139188448 hasPublicationYear "2002" @default.
• W2139188448 type Work @default.
• W2139188448 sameAs 2139188448 @default.
• W2139188448 citedByCount "150" @default.
• W2139188448 countsByYear W21391884482012 @default.
• W2139188448 countsByYear W21391884482013 @default.
• W2139188448 countsByYear W21391884482014 @default.
• W2139188448 countsByYear W21391884482015 @default.
• W2139188448 countsByYear W21391884482016 @default.
• W2139188448 countsByYear W21391884482017 @default.
• W2139188448 countsByYear W21391884482018 @default.
• W2139188448 countsByYear W21391884482019 @default.
• W2139188448 countsByYear W21391884482020 @default.
• W2139188448 countsByYear W21391884482021 @default.
• W2139188448 countsByYear W21391884482022 @default.
• W2139188448 countsByYear W21391884482023 @default.
• W2139188448 crossrefType "journal-article" @default.
• W2139188448 hasAuthorship W2139188448A5007934367 @default.
• W2139188448 hasAuthorship W2139188448A5023228042 @default.
• W2139188448 hasAuthorship W2139188448A5042850506 @default.
• W2139188448 hasAuthorship W2139188448A5053792416 @default.
• W2139188448 hasAuthorship W2139188448A5077542898 @default.
• W2139188448 hasAuthorship W2139188448A5084616489 @default.
• W2139188448 hasBestOaLocation W21391884481 @default.
• W2139188448 hasConcept C104317684 @default.
• W2139188448 hasConcept C126322002 @default.
• W2139188448 hasConcept C185592680 @default.
• W2139188448 hasConcept C205260736 @default.
• W2139188448 hasConcept C2777576037 @default.
• W2139188448 hasConcept C2779222958 @default.
• W2139188448 hasConcept C2781300812 @default.
• W2139188448 hasConcept C55493867 @default.
• W2139188448 hasConcept C71924100 @default.
• W2139188448 hasConcept C86803240 @default.
• W2139188448 hasConcept C95444343 @default.
• W2139188448 hasConceptScore W2139188448C104317684 @default.
• W2139188448 hasConceptScore W2139188448C126322002 @default.
• W2139188448 hasConceptScore W2139188448C185592680 @default.
• W2139188448 hasConceptScore W2139188448C205260736 @default.
• W2139188448 hasConceptScore W2139188448C2777576037 @default.
• W2139188448 hasConceptScore W2139188448C2779222958 @default.
• W2139188448 hasConceptScore W2139188448C2781300812 @default.
• W2139188448 hasConceptScore W2139188448C55493867 @default.
• W2139188448 hasConceptScore W2139188448C71924100 @default.
• W2139188448 hasConceptScore W2139188448C86803240 @default.
• W2139188448 hasConceptScore W2139188448C95444343 @default.
• W2139188448 hasIssue "47" @default.
• W2139188448 hasLocation W21391884481 @default.
• W2139188448 hasOpenAccess W2139188448 @default.
• W2139188448 hasPrimaryLocation W21391884481 @default.
• W2139188448 hasRelatedWork W1914372629 @default.
• W2139188448 hasRelatedWork W2009810460 @default.
• W2139188448 hasRelatedWork W2025917340 @default.
• W2139188448 hasRelatedWork W2026244176 @default.
• W2139188448 hasRelatedWork W2062385823 @default.
• W2139188448 hasRelatedWork W2078693732 @default.

• next