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• W2139212962 abstract "Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF-16a, a putative ortholog of Caenorhabditis elegans DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggests that B. malayi DAF-16a is a member of the FOXO family of forkhead proteins. Proteins 2014; 82:3490–3496. © 2014 Wiley Periodicals, Inc." @default.
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• W2139212962 date "2014-10-21" @default.
• W2139212962 modified "2023-09-26" @default.
• W2139212962 title "The solution structure of the forkhead box-ODNA binding domain ofBrugia malayiDAF-16a" @default.
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• W2139212962 doi "https://doi.org/10.1002/prot.24701" @default.
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