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• W2139220170 abstract "Docosahexaenoic acid (DHA), the end-product of the metabolism of omega-3 family fatty acids, is the main polyunsaturated fatty acid of the brain, but its accumulation is incompletely understood. This paper reviews how it could accumulate through specific uptake of DHA-containing lysophosphatidylcholine (LysoPC-DHA). DHA migrates very easily from the sn-2 position of LysoPC, which could be considered as the physiological form of polyunsaturated LysoPC, to the sn-1 position, which is much more stable. An approach preventing migration by acetylating the sn-1 position, while retaining the main physico-chemical properties of the carrier, is described. Also, the double lipoxygenation and bond-isomerization of DHA into 10(S),17(S)-docosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid, named PDX, by soybean lipoxygenase is described. As in other E,Z,E conjugated trienes, PDX is shown to inhibit human blood platelet aggregation at submicromolar concentrations." @default.
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• W2139220170 date "2010-04-28" @default.
• W2139220170 modified "2023-10-16" @default.
• W2139220170 title "DHA Metabolism: Targeting the Brain and Lipoxygenation" @default.
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• W2139220170 doi "https://doi.org/10.1007/s12035-010-8131-7" @default.
• W2139220170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2894371" @default.
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