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- W2139239470 abstract "Sixty-two patients with long established but symptomatic ankylosing spondylitis were treated with sulphasalazine or matching placebo in a randomized double-blind controlled trial for 48 weeks. There were no consistent significant differences between the treatment groups in clinical parameters despite multiple assessments. Equivalent numbers in each group were able to decrease or stop non-steroidal anti-inflammatory drug ingestion during the study period (four active, eight placebo). Side effects were reported more commonly in the sulphasalazine group (27 versus 17, NS), but only 21 patients stopped treatment because of side effects (12 versus 9, NS). Analysis of the subgroup with an initial ESR greater than 20 mm/h failed to show any persisting differences of response between sulphasalazine and placebo. We conclude that sulphasalazine therapy does not have a role in the treatment of chronic ankylosing spondylitis." @default.
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- W2139239470 date "1990-01-01" @default.
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- W2139239470 title "A CONTROLLED TRIAL OF SULPHASALAZINE TREATMENT OF CHRONIC ANKYLOSING SPONDYLITIS: FAILURE TODEMONSTRATE A CLINICAL EFFECT" @default.
- W2139239470 doi "https://doi.org/10.1093/rheumatology/29.1.41" @default.
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