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- W2139285527 startingPage "e43837" @default.
- W2139285527 abstract "We have analyzed natural variation in mitochondrial form and function among a set of Caenorhabditis briggsae isolates known to harbor mitochondrial DNA structural variation in the form of a heteroplasmic nad5 gene deletion (nad5Δ) that correlates negatively with organismal fitness. We performed in vivo quantification of 24 mitochondrial phenotypes including reactive oxygen species level, membrane potential, and aspects of organelle morphology, and observed significant among-isolate variation in 18 traits. Although several mitochondrial phenotypes were non-linearly associated with nad5Δ levels, most of the among-isolate phenotypic variation could be accounted for by phylogeographic clade membership. In particular, isolate-specific mitochondrial membrane potential was an excellent predictor of clade membership. We interpret this result in light of recent evidence for local adaptation to temperature in C. briggsae. Analysis of mitochondrial-nuclear hybrid strains provided support for both mtDNA and nuclear genetic variation as drivers of natural mitochondrial phenotype variation. This study demonstrates that multicellular eukaryotic species are capable of extensive natural variation in organellar phenotypes and highlights the potential of integrating evolutionary and cell biology perspectives." @default.
- W2139285527 created "2016-06-24" @default.
- W2139285527 creator A5009768579 @default.
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- W2139285527 creator A5065030704 @default.
- W2139285527 date "2012-08-28" @default.
- W2139285527 modified "2023-10-03" @default.
- W2139285527 title "In Vivo Quantification Reveals Extensive Natural Variation in Mitochondrial Form and Function in Caenorhabditis briggsae" @default.
- W2139285527 cites W1495825745 @default.
- W2139285527 cites W1500849516 @default.
- W2139285527 cites W1504597729 @default.
- W2139285527 cites W1604984248 @default.
- W2139285527 cites W1825823071 @default.
- W2139285527 cites W1963795151 @default.
- W2139285527 cites W1965701630 @default.
- W2139285527 cites W1967672708 @default.
- W2139285527 cites W1976139454 @default.
- W2139285527 cites W1977332628 @default.
- W2139285527 cites W1979048203 @default.
- W2139285527 cites W1979633540 @default.
- W2139285527 cites W1979705609 @default.
- W2139285527 cites W1983066766 @default.
- W2139285527 cites W1983879895 @default.
- W2139285527 cites W1996234796 @default.
- W2139285527 cites W1997360166 @default.
- W2139285527 cites W1997422422 @default.
- W2139285527 cites W2010094123 @default.
- W2139285527 cites W2010431679 @default.
- W2139285527 cites W2012264972 @default.
- W2139285527 cites W2012373720 @default.
- W2139285527 cites W2015638974 @default.
- W2139285527 cites W2021750095 @default.
- W2139285527 cites W2023542615 @default.
- W2139285527 cites W2024595059 @default.
- W2139285527 cites W2026509565 @default.
- W2139285527 cites W2026960323 @default.
- W2139285527 cites W2030145039 @default.
- W2139285527 cites W2034431038 @default.
- W2139285527 cites W2036596850 @default.
- W2139285527 cites W2037855135 @default.
- W2139285527 cites W2037951418 @default.
- W2139285527 cites W2038323003 @default.
- W2139285527 cites W2039093830 @default.
- W2139285527 cites W2041835091 @default.
- W2139285527 cites W2043829591 @default.
- W2139285527 cites W2044494908 @default.
- W2139285527 cites W2044747701 @default.
- W2139285527 cites W2063382649 @default.
- W2139285527 cites W2067410194 @default.
- W2139285527 cites W2072261604 @default.
- W2139285527 cites W2073579049 @default.
- W2139285527 cites W2078139350 @default.
- W2139285527 cites W2079659465 @default.
- W2139285527 cites W2082882491 @default.
- W2139285527 cites W2083720450 @default.
- W2139285527 cites W2083899719 @default.
- W2139285527 cites W2084621494 @default.
- W2139285527 cites W2085396235 @default.
- W2139285527 cites W2086576625 @default.
- W2139285527 cites W2086576678 @default.
- W2139285527 cites W2090738704 @default.
- W2139285527 cites W2092309784 @default.
- W2139285527 cites W2093988460 @default.
- W2139285527 cites W2094421676 @default.
- W2139285527 cites W2097239618 @default.
- W2139285527 cites W2100659636 @default.
- W2139285527 cites W2104952200 @default.
- W2139285527 cites W2105144460 @default.
- W2139285527 cites W2108049416 @default.
- W2139285527 cites W2121503267 @default.
- W2139285527 cites W2121966499 @default.
- W2139285527 cites W2122341467 @default.
- W2139285527 cites W2123004132 @default.
- W2139285527 cites W2126624770 @default.
- W2139285527 cites W2130497877 @default.
- W2139285527 cites W2130995821 @default.
- W2139285527 cites W2131768903 @default.
- W2139285527 cites W2132579877 @default.
- W2139285527 cites W2133331872 @default.
- W2139285527 cites W2134891434 @default.
- W2139285527 cites W2135588013 @default.
- W2139285527 cites W2136046510 @default.
- W2139285527 cites W2136937485 @default.
- W2139285527 cites W2141201649 @default.
- W2139285527 cites W2141901922 @default.
- W2139285527 cites W2145882912 @default.
- W2139285527 cites W2149120324 @default.
- W2139285527 cites W2151698573 @default.
- W2139285527 cites W2152363514 @default.
- W2139285527 cites W2155265427 @default.
- W2139285527 cites W2157299674 @default.
- W2139285527 cites W2165198127 @default.
- W2139285527 cites W2171215342 @default.
- W2139285527 cites W2171810396 @default.
- W2139285527 cites W2176275556 @default.
- W2139285527 cites W2187370199 @default.