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• W2139287303 abstract "The ADP/ATP carrier (AAC) proteins play a central role in cellular metabolism as they facilitate the exchange of ADP and ATP across the mitochondrial inner membrane. We present evidence here that in yeast (Saccharomyces cerevisiae) mitochondria the abundant Aac2 isoform exists in physical association with the cytochrome c reductase (cytochrome bc(1))-cytochrome c oxidase (COX) supercomplex and its associated TIM23 machinery. Using a His-tagged Aac2 derivative and affinity purification studies, we also demonstrate here that the Aac2 isoform can be affinity-purified with other AAC proteins. Copurification of the Aac2 protein with the TIM23 machinery can occur independently of its association with the fully assembled cytochrome bc(1)-COX supercomplex. In the absence of the Aac2 protein, the assembly of the cytochrome bc(1)-COX supercomplex is perturbed, whereby a decrease in the III(2)-IV(2) assembly state relative to the III(2)-IV form is observed. We propose that the association of the Aac2 protein with the cytochrome bc(1)-COX supercomplex is important for the function of the OXPHOS complexes and for the assembly of the COX complex. The physiological implications of the association of AAC with the cytochrome bc(1)-COX-TIM23 supercomplex are also discussed." @default.
• W2139287303 created "2016-06-24" @default.
• W2139287303 creator A5055485265 @default.
• W2139287303 creator A5076951125 @default.
• W2139287303 date "2008-09-01" @default.
• W2139287303 modified "2023-10-12" @default.
• W2139287303 title "The Yeast Aac2 Protein Exists in Physical Association with the Cytochrome<i>bc</i>₁-COX Supercomplex and the TIM23 Machinery" @default.
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• W2139287303 doi "https://doi.org/10.1091/mbc.e08-04-0402" @default.
• W2139287303 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2526699" @default.
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