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- W2139290526 abstract "Bisphosphonates are commonly used for treatment of osteoporosis. They inhibit osteoclast ac- tivity and thus bone resorption. It was shown that they also affect some other cell types including tu- mour and endothelial cells. The effects of risedronate on bone marrow microenvironment were not studied yet. As endothelial cells are integral part of bone marrow microenvironment, it is important to know whether prolonged administration of bisphospho- nates does not affect haematopoietic stem cells and bone marrow haematopoiesis. We fed mice two weeks with risedronate. We found no effect of risedronate treatment on bone marrow stem cells using the meth- od of congenic bone marrow repopulation. Risedro- nate administration in the dose which is considered to be comparable to a dose of risedronate used for treatment of osteoporosis in women seems to be safe in terms of effects on mouse haematopoiesis." @default.
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- W2139290526 date "2007-01-01" @default.
- W2139290526 modified "2023-10-16" @default.
- W2139290526 title "Short Communication Risedronate Has No Adverse Effects on Mouse Haematopoiesis" @default.
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