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- W2139293151 abstract "<h3>Background</h3> In patients with multiple sclerosis (MS), motor tasks are associated with increased activation of ipsilateral motor cortical areas. The authors examined the role of two ipsilateral motor areas during performance of a simple motor task in MS patients in relation to their motor impairment and CNS injury. <h3>Methods</h3> Single pulses of transcranial magnetic stimulation (TMS) were used to interfere transiently with neuronal processing in the contralateral (M1<sub>CONTRA</sub>) or ipsilateral (M1<sub>IPSI</sub>) primary motor cortex or ipsilateral dorsal premotor cortex (PMd<sub>IPSI</sub>) during a simple reaction time (RT) task in 26 right-handed patients with moderately severe stable MS and matched healthy controls. Subjects responded to an auditorily presented Go signal as quickly as possible by performing isometric right-thumb abductions. TMS was applied 100 ms after the Go signal. Motor impairment was evaluated by hand function tests. CNS injury was assessed by magnetic resonance spectroscopy (normalised N-acetyl-aspartate spectra, NAA/Cr), by the total cerebral T2-weighted MRI hyperintense lesion load, and by corticomuscular latency (CML) to the abductor pollicis brevis muscle. <h3>Results</h3> TMS applied to M1<sub>CONTRA</sub> slowed RT in patients and controls. In contrast, stimulation of M1<sub>IPSI</sub> or PMd<sub>IPSI</sub> increased RT only in MS patients. In patients, the relative RT changes following TMS over M1<sub>IPSI</sub> or PMd<sub>IPSI</sub> did not correlate with any of the motor function tests or with NAA/Cr or total cerebral lesion load. However, RT changes following TMS over M1<sub>IPSI</sub> correlated inversely with CML. <h3>Conclusions</h3> Recruitment of ipsilateral motor areas may be a functionally relevant, yet limited adaptive response to chronic brain injury in MS patients." @default.
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- W2139293151 date "2010-10-27" @default.
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- W2139293151 title "Functional role of ipsilateral motor areas in multiple sclerosis" @default.
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- W2139293151 doi "https://doi.org/10.1136/jnnp.2010.219964" @default.
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