FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139304826> ?p ?o ?g. }

• W2139304826 endingPage "3832" @default.
• W2139304826 startingPage "3824" @default.
• W2139304826 abstract "Streptococcus oligofermentans is an oral commensal that inhibits the growth of the caries pathogen Streptococcus mutans by producing copious amounts of H(2)O(2) and that grows faster than S. mutans on galactose. In this study, we identified a novel eight-gene galactose (gal) operon in S. oligofermentans that was comprised of lacABCD, lacX, and three genes encoding a galactose-specific transporter. Disruption of lacA caused more growth reduction on galactose than mutation of galK, a gene in the Leloir pathway, indicating that the principal role of this operon is in galactose metabolism. Diauxic growth was observed in cultures containing glucose and galactose, and a luciferase reporter fusion to the putative gal promoter demonstrated 12-fold repression of the operon expression by glucose but was induced by galactose, suggesting a carbon catabolite repression (CCR) control in galactose utilization. Interestingly, none of the single-gene mutations in the well-known CCR regulators ccpA and manL affected diauxic growth, although the operon expression was upregulated in these mutants in glucose. A double mutation of ccpA and manL eliminated glucose repression of galactose utilization, suggesting that these genes have parallel functions in regulating gal operon expression and mediating CCR. Electrophoretic mobility shift assays demonstrated binding of CcpA to the putative catabolite response element motif in the promoter regions of the gal operon and manL, suggesting that CcpA regulates CCR through direct regulation of the transcription of the gal operon and manL. This provides the first example of oral streptococci using two parallel CcpA-dependent CCR pathways in controlling carbohydrate metabolism." @default.
• W2139304826 created "2016-06-24" @default.
• W2139304826 creator A5020638539 @default.
• W2139304826 creator A5031924369 @default.
• W2139304826 creator A5034113666 @default.
• W2139304826 creator A5054938952 @default.
• W2139304826 date "2012-08-01" @default.
• W2139304826 modified "2023-10-16" @default.
• W2139304826 title "CcpA-Dependent Carbohydrate Catabolite Repression Regulates Galactose Metabolism in Streptococcus oligofermentans" @default.
• W2139304826 cites W1556498201 @default.
• W2139304826 cites W1571742789 @default.
• W2139304826 cites W1843970506 @default.
• W2139304826 cites W1903247097 @default.
• W2139304826 cites W1977782657 @default.
• W2139304826 cites W1978121928 @default.
• W2139304826 cites W1980376537 @default.
• W2139304826 cites W1987842533 @default.
• W2139304826 cites W1993184830 @default.
• W2139304826 cites W1999920042 @default.
• W2139304826 cites W2009274118 @default.
• W2139304826 cites W2017529960 @default.
• W2139304826 cites W2021715275 @default.
• W2139304826 cites W2031855650 @default.
• W2139304826 cites W2036449301 @default.
• W2139304826 cites W2038683612 @default.
• W2139304826 cites W2046118138 @default.
• W2139304826 cites W2049104376 @default.
• W2139304826 cites W2058911298 @default.
• W2139304826 cites W2073077653 @default.
• W2139304826 cites W2092259419 @default.
• W2139304826 cites W2095207888 @default.
• W2139304826 cites W2098544115 @default.
• W2139304826 cites W2103805072 @default.
• W2139304826 cites W2107190117 @default.
• W2139304826 cites W2112793784 @default.
• W2139304826 cites W2114126023 @default.
• W2139304826 cites W2116984091 @default.
• W2139304826 cites W2117522399 @default.
• W2139304826 cites W2119453590 @default.
• W2139304826 cites W2121163342 @default.
• W2139304826 cites W2123569104 @default.
• W2139304826 cites W2125107482 @default.
• W2139304826 cites W2125696007 @default.
• W2139304826 cites W2130394726 @default.
• W2139304826 cites W2132219663 @default.
• W2139304826 cites W2138331549 @default.
• W2139304826 cites W2139655216 @default.
• W2139304826 cites W2140206814 @default.
• W2139304826 cites W2141883257 @default.
• W2139304826 cites W2148337956 @default.
• W2139304826 cites W2150981918 @default.
• W2139304826 cites W2156599327 @default.
• W2139304826 cites W2160467552 @default.
• W2139304826 cites W2162953780 @default.
• W2139304826 cites W2166374078 @default.
• W2139304826 cites W2168065500 @default.
• W2139304826 cites W2168614234 @default.
• W2139304826 cites W2750525638 @default.
• W2139304826 cites W4249075929 @default.
• W2139304826 doi "https://doi.org/10.1128/jb.00156-12" @default.
• W2139304826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3416513" @default.
• W2139304826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22609925" @default.
• W2139304826 hasPublicationYear "2012" @default.
• W2139304826 type Work @default.
• W2139304826 sameAs 2139304826 @default.
• W2139304826 citedByCount "10" @default.
• W2139304826 countsByYear W21393048262013 @default.
• W2139304826 countsByYear W21393048262014 @default.
• W2139304826 countsByYear W21393048262015 @default.
• W2139304826 countsByYear W21393048262016 @default.
• W2139304826 countsByYear W21393048262018 @default.
• W2139304826 countsByYear W21393048262019 @default.
• W2139304826 countsByYear W21393048262021 @default.
• W2139304826 countsByYear W21393048262023 @default.
• W2139304826 crossrefType "journal-article" @default.
• W2139304826 hasAuthorship W2139304826A5020638539 @default.
• W2139304826 hasAuthorship W2139304826A5031924369 @default.
• W2139304826 hasAuthorship W2139304826A5034113666 @default.
• W2139304826 hasAuthorship W2139304826A5054938952 @default.
• W2139304826 hasBestOaLocation W21393048261 @default.
• W2139304826 hasConcept C104317684 @default.
• W2139304826 hasConcept C143065580 @default.
• W2139304826 hasConcept C150194340 @default.
• W2139304826 hasConcept C170344550 @default.
• W2139304826 hasConcept C203075996 @default.
• W2139304826 hasConcept C2778173381 @default.
• W2139304826 hasConcept C2781225136 @default.
• W2139304826 hasConcept C37150987 @default.
• W2139304826 hasConcept C55493867 @default.
• W2139304826 hasConcept C69953675 @default.
• W2139304826 hasConcept C83941689 @default.
• W2139304826 hasConcept C86803240 @default.
• W2139304826 hasConcept C89423630 @default.
• W2139304826 hasConceptScore W2139304826C104317684 @default.
• W2139304826 hasConceptScore W2139304826C143065580 @default.
• W2139304826 hasConceptScore W2139304826C150194340 @default.
• W2139304826 hasConceptScore W2139304826C170344550 @default.
• W2139304826 hasConceptScore W2139304826C203075996 @default.

• next