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- W2139312181 endingPage "144" @default.
- W2139312181 startingPage "129" @default.
- W2139312181 abstract "Splice site selection is fundamental to pre-mRNA splicing and the expansion of genomic coding potential. 5' Splice sites (5'ss) are the critical elements at the 5' end of introns and are extremely diverse, as thousands of different sequences act as bona fide 5'ss in the human transcriptome. Most 5'ss are recognized by base-pairing with the 5' end of the U1 small nuclear RNA (snRNA). Here we review the history of research on 5'ss selection, highlighting the difficulties of establishing how base-pairing strength determines splicing outcomes. We also discuss recent work demonstrating that U1 snRNA:5'ss helices can accommodate noncanonical registers such as bulged duplexes. In addition, we describe the mechanisms by which other snRNAs, regulatory proteins, splicing enhancers, and the relative positions of alternative 5'ss contribute to selection. Moreover, we discuss mechanisms by which the recognition of numerous candidate 5'ss might lead to selection of a single 5'ss and propose that protein complexes propagate along the exon, thereby changing its physical behavior so as to affect 5'ss selection." @default.
- W2139312181 created "2016-06-24" @default.
- W2139312181 creator A5029149817 @default.
- W2139312181 creator A5061029876 @default.
- W2139312181 creator A5084802567 @default.
- W2139312181 date "2013-01-15" @default.
- W2139312181 modified "2023-10-14" @default.
- W2139312181 title "Pick one, but be quick: 5′ splice sites and the problems of too many choices" @default.
- W2139312181 cites W1008280890 @default.
- W2139312181 cites W1553769217 @default.
- W2139312181 cites W1563462044 @default.
- W2139312181 cites W1593559195 @default.
- W2139312181 cites W1605045344 @default.
- W2139312181 cites W1795122982 @default.
- W2139312181 cites W1861998732 @default.
- W2139312181 cites W1871905727 @default.
- W2139312181 cites W1965463749 @default.
- W2139312181 cites W1967536639 @default.
- W2139312181 cites W1968223204 @default.
- W2139312181 cites W1968569455 @default.
- W2139312181 cites W1968843636 @default.
- W2139312181 cites W1969117624 @default.
- W2139312181 cites W1969457282 @default.
- W2139312181 cites W1973916539 @default.
- W2139312181 cites W1974293813 @default.
- W2139312181 cites W1975014999 @default.
- W2139312181 cites W1976249889 @default.
- W2139312181 cites W1977797456 @default.
- W2139312181 cites W1978020758 @default.
- W2139312181 cites W1979455742 @default.
- W2139312181 cites W1979722960 @default.
- W2139312181 cites W1979898379 @default.
- W2139312181 cites W1979907792 @default.
- W2139312181 cites W1982610079 @default.
- W2139312181 cites W1984586494 @default.
- W2139312181 cites W1987403693 @default.
- W2139312181 cites W1993816390 @default.
- W2139312181 cites W1994823144 @default.
- W2139312181 cites W1994940904 @default.
- W2139312181 cites W1995477021 @default.
- W2139312181 cites W1996948250 @default.
- W2139312181 cites W1998434274 @default.
- W2139312181 cites W2001064072 @default.
- W2139312181 cites W2003016053 @default.
- W2139312181 cites W2004698136 @default.
- W2139312181 cites W2005039213 @default.
- W2139312181 cites W2007526989 @default.
- W2139312181 cites W2008139645 @default.
- W2139312181 cites W2008467118 @default.
- W2139312181 cites W2009818318 @default.
- W2139312181 cites W2013235753 @default.
- W2139312181 cites W2014056463 @default.
- W2139312181 cites W2014181394 @default.
- W2139312181 cites W2015749400 @default.
- W2139312181 cites W2015809578 @default.
- W2139312181 cites W2020164044 @default.
- W2139312181 cites W2020266352 @default.
- W2139312181 cites W2021033136 @default.
- W2139312181 cites W2021581554 @default.
- W2139312181 cites W2023018590 @default.
- W2139312181 cites W2023199595 @default.
- W2139312181 cites W2024170620 @default.
- W2139312181 cites W2024540147 @default.
- W2139312181 cites W2024588724 @default.
- W2139312181 cites W2026601158 @default.
- W2139312181 cites W2026657651 @default.
- W2139312181 cites W2028363713 @default.
- W2139312181 cites W2028484611 @default.
- W2139312181 cites W2030606891 @default.
- W2139312181 cites W2032789712 @default.
- W2139312181 cites W2034691490 @default.
- W2139312181 cites W2038644462 @default.
- W2139312181 cites W2041847911 @default.
- W2139312181 cites W2041918235 @default.
- W2139312181 cites W2042570087 @default.
- W2139312181 cites W2045047064 @default.
- W2139312181 cites W2045300068 @default.
- W2139312181 cites W2045775938 @default.
- W2139312181 cites W2045936988 @default.
- W2139312181 cites W2045984686 @default.
- W2139312181 cites W2046335009 @default.
- W2139312181 cites W2051281200 @default.
- W2139312181 cites W205169601 @default.
- W2139312181 cites W2052018389 @default.
- W2139312181 cites W2052731608 @default.
- W2139312181 cites W2054865688 @default.
- W2139312181 cites W2056403897 @default.
- W2139312181 cites W2057479447 @default.
- W2139312181 cites W2058413149 @default.
- W2139312181 cites W2064350570 @default.
- W2139312181 cites W2065262709 @default.
- W2139312181 cites W2066988228 @default.
- W2139312181 cites W2067096868 @default.
- W2139312181 cites W2071336621 @default.
- W2139312181 cites W2073105366 @default.
- W2139312181 cites W2073189829 @default.
- W2139312181 cites W2073387857 @default.
- W2139312181 cites W2073398027 @default.