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• W2139333026 endingPage "2818" @default.
• W2139333026 startingPage "2808" @default.
• W2139333026 abstract "Many bacteria convert bicyclic compounds, such as indole and naphthalene, to oxidized compounds, including hydroxyindoles and naphthols. Pseudomonas aeruginosa, a ubiquitous bacterium that inhabits diverse environments, shows pathogenicity against animals, plants, and other microorganisms, and increasing evidence has shown that several bicyclic compounds alter the virulence-related phenotypes of P. aeruginosa. Here, we revealed that hydroxyindoles (4- and 5-hydroxyindoles) and naphthalene derivatives bearing hydroxyl groups specifically inhibit swarming motility but have minor effects on other motilities, including swimming and twitching, in P. aeruginosa. Further analyses using 1-naphthol showed that this effect is also associated with clinically isolated hyperswarming P. aeruginosa cells. Swarming motility is associated with the dispersion of cells from biofilms, and the addition of 1-naphthol maintained biofilm biomass without cell dispersion. We showed that this 1-naphthol-dependent swarming inhibition is independent of changes of rhamnolipid production and the intracellular level of signaling molecule cyclic-di-GMP (c-di-GMP). Transcriptome analyses revealed that 1-naphthol increases gene expression associated with multidrug efflux and represses gene expression associated with aerotaxis and with pyochelin, flagellar, and pilus synthesis. In the present study, we showed that several bicyclic compounds bearing hydroxyl groups inhibit the swarming motility of P. aeruginosa, and these results provide new insight into the chemical structures that inhibit the specific phenotypes of P. aeruginosa." @default.
• W2139333026 created "2016-06-24" @default.
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• W2139333026 date "2015-04-15" @default.
• W2139333026 modified "2023-10-03" @default.
• W2139333026 title "Inhibition of Pseudomonas aeruginosa Swarming Motility by 1-Naphthol and Other Bicyclic Compounds Bearing Hydroxyl Groups" @default.
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• W2139333026 doi "https://doi.org/10.1128/aem.04220-14" @default.
• W2139333026 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4375311" @default.
• W2139333026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25681177" @default.
• W2139333026 hasPublicationYear "2015" @default.
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