FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139351162> ?p ?o ?g. }

• W2139351162 endingPage "939" @default.
• W2139351162 startingPage "929" @default.
• W2139351162 abstract "Abstract Some naturally occurring flavonols, exemplified by quercetin, seem to possess experimental cancer chemopreventive efficacy. Modulation of p53 is a mechanism thought to contribute to their activity. The hypothesis was tested that a synthetic flavonol, 3′,4′,5′-trimethoxyflavonol (TMFol), can interfere with tumor development and p53 expression in two models of colorectal carcinogenesis, ApcMin mice and human-derived HCT116 adenocarcinoma–bearing nude mice. Mice received TMFol with their diet (0.2%) from weaning to week 16 in the case of ApcMin or from either day 7 before (“TMFol early”) or day 7 after (“TMFol late”) tumor inoculation in HCT116 mice. The ability of TMFol to affect tumor proliferation or apoptosis, as reflected by staining for Ki-67 or cleaved caspase-3, respectively, was studied in HCT116 tumors. TMFol tumor levels were measured by high-performance liquid chromatography. Consumption of TMFol reduced small intestinal adenoma burden in ApcMin mice by 47%, compared with control mice (P &lt; 0.002). The TMFol early regimen approximately halved HCT116 tumor size (P &lt; 0.05), decreased tumor proliferation, and increased apoptosis, whereas the TMFol late regimen had no significant effect when compared with controls. In tumor tissues from mice, in which TMFol reduced tumor development, p53 expression was increased 3-fold in ApcMin and 1.5-fold in HCT116 tumor–bearing mice (P = 0.02). TMFol increased p53 also in cells derived from these tumors. TMFol was detected in HCT116 tumors, but levels did not correlate with tumor burden. TMFol was not mutagenic in the Ames test. The results suggest that chemical modification of the flavonol structure may generate safe and efficacious cancer chemopreventive agents. Cancer Prev Res; 3(8); 929–39. ©2010 AACR." @default.
• W2139351162 created "2016-06-24" @default.
• W2139351162 creator A5031111647 @default.
• W2139351162 creator A5047123940 @default.
• W2139351162 creator A5053371660 @default.
• W2139351162 creator A5058052872 @default.
• W2139351162 creator A5058567743 @default.
• W2139351162 creator A5081854469 @default.
• W2139351162 creator A5087576978 @default.
• W2139351162 creator A5090645051 @default.
• W2139351162 creator A5091714925 @default.
• W2139351162 date "2010-08-01" @default.
• W2139351162 modified "2023-10-14" @default.
• W2139351162 title "Preclinical Colorectal Cancer Chemopreventive Efficacy and p53-Modulating Activity of 3′,4′,5′-Trimethoxyflavonol, a Quercetin Analogue" @default.
• W2139351162 cites W1974917142 @default.
• W2139351162 cites W1985753549 @default.
• W2139351162 cites W1990979855 @default.
• W2139351162 cites W2001781880 @default.
• W2139351162 cites W2007869047 @default.
• W2139351162 cites W2011912935 @default.
• W2139351162 cites W2013166418 @default.
• W2139351162 cites W2015322909 @default.
• W2139351162 cites W2028804965 @default.
• W2139351162 cites W2029416355 @default.
• W2139351162 cites W2030627261 @default.
• W2139351162 cites W2038193795 @default.
• W2139351162 cites W2047596219 @default.
• W2139351162 cites W2056594432 @default.
• W2139351162 cites W2057111247 @default.
• W2139351162 cites W2057830803 @default.
• W2139351162 cites W2059881760 @default.
• W2139351162 cites W2063675387 @default.
• W2139351162 cites W2070312673 @default.
• W2139351162 cites W2073260783 @default.
• W2139351162 cites W2078427351 @default.
• W2139351162 cites W2088236232 @default.
• W2139351162 cites W2093137668 @default.
• W2139351162 cites W2098671913 @default.
• W2139351162 cites W2102681375 @default.
• W2139351162 cites W2114899799 @default.
• W2139351162 cites W2128954527 @default.
• W2139351162 cites W2141647078 @default.
• W2139351162 cites W2142285790 @default.
• W2139351162 cites W2147327518 @default.
• W2139351162 cites W2149482571 @default.
• W2139351162 cites W2154377786 @default.
• W2139351162 cites W2155127143 @default.
• W2139351162 cites W2156445427 @default.
• W2139351162 cites W2330709704 @default.
• W2139351162 cites W2479044294 @default.
• W2139351162 doi "https://doi.org/10.1158/1940-6207.capr-09-0236" @default.
• W2139351162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2917785" @default.
• W2139351162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20628003" @default.
• W2139351162 hasPublicationYear "2010" @default.
• W2139351162 type Work @default.
• W2139351162 sameAs 2139351162 @default.
• W2139351162 citedByCount "23" @default.
• W2139351162 countsByYear W21393511622012 @default.
• W2139351162 countsByYear W21393511622013 @default.
• W2139351162 countsByYear W21393511622015 @default.
• W2139351162 countsByYear W21393511622016 @default.
• W2139351162 countsByYear W21393511622018 @default.
• W2139351162 countsByYear W21393511622019 @default.
• W2139351162 countsByYear W21393511622022 @default.
• W2139351162 crossrefType "journal-article" @default.
• W2139351162 hasAuthorship W2139351162A5031111647 @default.
• W2139351162 hasAuthorship W2139351162A5047123940 @default.
• W2139351162 hasAuthorship W2139351162A5053371660 @default.
• W2139351162 hasAuthorship W2139351162A5058052872 @default.
• W2139351162 hasAuthorship W2139351162A5058567743 @default.
• W2139351162 hasAuthorship W2139351162A5081854469 @default.
• W2139351162 hasAuthorship W2139351162A5087576978 @default.
• W2139351162 hasAuthorship W2139351162A5090645051 @default.
• W2139351162 hasAuthorship W2139351162A5091714925 @default.
• W2139351162 hasBestOaLocation W21393511621 @default.
• W2139351162 hasConcept C114246631 @default.
• W2139351162 hasConcept C121608353 @default.
• W2139351162 hasConcept C126322002 @default.
• W2139351162 hasConcept C134018914 @default.
• W2139351162 hasConcept C190283241 @default.
• W2139351162 hasConcept C2777428134 @default.
• W2139351162 hasConcept C2779256057 @default.
• W2139351162 hasConcept C2780122803 @default.
• W2139351162 hasConcept C2780669762 @default.
• W2139351162 hasConcept C3018440083 @default.
• W2139351162 hasConcept C502942594 @default.
• W2139351162 hasConcept C526805850 @default.
• W2139351162 hasConcept C55493867 @default.
• W2139351162 hasConcept C555283112 @default.
• W2139351162 hasConcept C71924100 @default.
• W2139351162 hasConcept C86803240 @default.
• W2139351162 hasConceptScore W2139351162C114246631 @default.
• W2139351162 hasConceptScore W2139351162C121608353 @default.
• W2139351162 hasConceptScore W2139351162C126322002 @default.
• W2139351162 hasConceptScore W2139351162C134018914 @default.
• W2139351162 hasConceptScore W2139351162C190283241 @default.
• W2139351162 hasConceptScore W2139351162C2777428134 @default.
• W2139351162 hasConceptScore W2139351162C2779256057 @default.

• next