Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139360219> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2139360219 abstract "Celecoxib is a selective cyclo-oxygenase 2 inhibitor that relieves pain without affecting platelet function, causing gastrointestinal toxic effects, or increasing the risk of bleeding.To develop a suspension formulation for oral celecoxib and to determine its physical and chemical stability when packaged in amber polyvinyl chloride (PVC) bottles and stored with refrigeration (5°C) and at room temperature (23°C).The contents of celecoxib capsules were used to prepare a single suspension, with Ora-Blend used as the suspending and flavouring agent. The suspension (10 mg/mL) was then packaged in amber PVC bottles and stored at either 5°C or 23°C. Samples were collected on days 0, 7, 14, 21, 27, 56, and 93. Chemical stability was determined using a validated stability-indicating high-performance liquid chromatography method. At each sampling time, the suspensions were checked visually for changes in appearance (i.e., colour, layering, caking, and ease of resuspension), odour, and pH.All of the suspensions were stable for at least 93 days, regardless of storage conditions. There were no apparent changes in physical appearance, nor were there any substantial changes in odour or pH.Suspensions of celecoxib (10 mg/mL in Ora-Blend) packaged in amber PVC bottles were stable for up to 93 days when stored at 5°C or 23°C. A 3-month expiry date has been established for this oral suspension on the basis of physical compatibility and chemical stability." @default.
- W2139360219 created "2016-06-24" @default.
- W2139360219 creator A5010694910 @default.
- W2139360219 creator A5034364221 @default.
- W2139360219 creator A5047939458 @default.
- W2139360219 creator A5085931972 @default.
- W2139360219 date "2009-12-10" @default.
- W2139360219 modified "2023-10-01" @default.
- W2139360219 title "Stability of Celecoxib Oral Suspension" @default.
- W2139360219 cites W1576018319 @default.
- W2139360219 cites W1990236005 @default.
- W2139360219 cites W2028000581 @default.
- W2139360219 cites W2079610142 @default.
- W2139360219 cites W2091464566 @default.
- W2139360219 cites W2102498885 @default.
- W2139360219 cites W2121911388 @default.
- W2139360219 cites W2144969116 @default.
- W2139360219 doi "https://doi.org/10.4212/cjhp.v62i6.844" @default.
- W2139360219 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2827017" @default.
- W2139360219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22478934" @default.
- W2139360219 hasPublicationYear "2009" @default.
- W2139360219 type Work @default.
- W2139360219 sameAs 2139360219 @default.
- W2139360219 citedByCount "5" @default.
- W2139360219 countsByYear W21393602192013 @default.
- W2139360219 countsByYear W21393602192015 @default.
- W2139360219 countsByYear W21393602192017 @default.
- W2139360219 crossrefType "journal-article" @default.
- W2139360219 hasAuthorship W2139360219A5010694910 @default.
- W2139360219 hasAuthorship W2139360219A5034364221 @default.
- W2139360219 hasAuthorship W2139360219A5047939458 @default.
- W2139360219 hasAuthorship W2139360219A5085931972 @default.
- W2139360219 hasBestOaLocation W21393602191 @default.
- W2139360219 hasConcept C105341887 @default.
- W2139360219 hasConcept C178790620 @default.
- W2139360219 hasConcept C185592680 @default.
- W2139360219 hasConcept C186399102 @default.
- W2139360219 hasConcept C202444582 @default.
- W2139360219 hasConcept C2776467144 @default.
- W2139360219 hasConcept C2776866176 @default.
- W2139360219 hasConcept C33923547 @default.
- W2139360219 hasConcept C43617362 @default.
- W2139360219 hasConcept C55493867 @default.
- W2139360219 hasConcept C5961521 @default.
- W2139360219 hasConceptScore W2139360219C105341887 @default.
- W2139360219 hasConceptScore W2139360219C178790620 @default.
- W2139360219 hasConceptScore W2139360219C185592680 @default.
- W2139360219 hasConceptScore W2139360219C186399102 @default.
- W2139360219 hasConceptScore W2139360219C202444582 @default.
- W2139360219 hasConceptScore W2139360219C2776467144 @default.
- W2139360219 hasConceptScore W2139360219C2776866176 @default.
- W2139360219 hasConceptScore W2139360219C33923547 @default.
- W2139360219 hasConceptScore W2139360219C43617362 @default.
- W2139360219 hasConceptScore W2139360219C55493867 @default.
- W2139360219 hasConceptScore W2139360219C5961521 @default.
- W2139360219 hasLocation W21393602191 @default.
- W2139360219 hasLocation W21393602192 @default.
- W2139360219 hasLocation W21393602193 @default.
- W2139360219 hasLocation W21393602194 @default.
- W2139360219 hasOpenAccess W2139360219 @default.
- W2139360219 hasPrimaryLocation W21393602191 @default.
- W2139360219 isParatext "false" @default.
- W2139360219 isRetracted "false" @default.
- W2139360219 magId "2139360219" @default.
- W2139360219 workType "article" @default.