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• W2139372100 abstract "In the present study, the dose related effect of the aqueous seed extract of Carica papaya Linn. extract(CPE) was evaluated by pre-treating three groups of rats (made up of six male rats per group) with 100– 400 mg/kg body weight per oral of the extract for 7 days before challenging with 1.5 ml/kg body weightof 20% carbon tetrachloride in olive oil in addition to the untreated control and model control rats. Also,the time-course effect of 400 mg/kg per oral of the extract were determined at 3 hr pre-, 0 hr, 1 hr post-,3 hr post-, and 6 hr post-CCl4 induction, respectively, in addition to the untreated control and modelcontrol groups. After 72 hours, serum levels of uric acid, urea and creatinine of all study groups weremeasured using standard procedures. Histological studies of rat kidneys of all study groups were alsodone. Results showed that intraperitoneal injection of CCl4 caused a significant (p<0.001) elevation inthe serum levels of uric acid, urea and creatinine and induced histological features of severe tubulointerstitial necrosis. However, elevations in the measured biochemical parameters were significantly (p<0.05, p<0.01 and p<0.001) attenuated in rats pre-treated with the graded oral doses of the extract, in dose related fashion. Maximum nephroprotection was offered by the extract at 400 mg/kg/day CPE which lasted up to 3 hours post-CCl4 exposure and these biochemical evidences were corroborated by improvements in the renal histological lesions induced by CCl4 intoxication. In conclusion, our study showed that CPE has nephroprotective effect on CCl4 renal injured rats, an effect which could be mediated by any of the phytocomponents present in it via either antioxidant and/or free radicalscavenging mechanism(s)." @default.
• W2139372100 created "2016-06-24" @default.
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• W2139372100 date "2009-01-01" @default.
• W2139372100 modified "2023-09-24" @default.
• W2139372100 title "Preliminary hypoglycemic and hypolipidemic activities of the aqueousseed extract of Carica papaya Linn. in Wistar rats" @default.
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• W2139372100 doi "https://doi.org/10.4172/0974-8369.1000001" @default.
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