FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139388314> ?p ?o ?g. }

• W2139388314 endingPage "1142" @default.
• W2139388314 startingPage "1131" @default.
• W2139388314 abstract "Lantibiotics are antimicrobial peptides that have been the focus of much attention in recent years with a view to clinical, veterinary, and food applications. Although many lantibiotics are produced by food-grade bacteria or bacteria generally regarded as safe, some lantibiotics are produced by pathogens and, rather than contributing to food safety and/or health, add to the virulence potential of the producing strains. Indeed, genome sequencing has revealed the presence of genes apparently encoding a lantibiotic, designated Bsa (bacteriocin of Staphylococcus aureus), among clinical isolates of S. aureus and those associated with community-acquired methicillin-resistant S. aureus (MRSA) infections in particular. Here, we establish for the first time, through a combination of reverse genetics, mass spectrometry, and mutagenesis, that these genes encode a functional lantibiotic. We also reveal that Bsa is identical to the previously identified bacteriocin staphylococcin Au-26, produced by an S. aureus strain of vaginal origin. Our examination of MRSA isolates that produce the Panton-Valentine leukocidin demonstrates that many community-acquired S. aureus strains, and representatives of ST8 and ST80 in particular, are producers of Bsa. While possession of Bsa immunity genes does not significantly enhance resistance to the related lantibiotic gallidermin, the broad antimicrobial spectrum of Bsa strongly indicates that production of this bacteriocin confers a competitive ecological advantage on community-acquired S. aureus." @default.
• W2139388314 created "2016-06-24" @default.
• W2139388314 creator A5005085411 @default.
• W2139388314 creator A5014079362 @default.
• W2139388314 creator A5018551532 @default.
• W2139388314 creator A5032975513 @default.
• W2139388314 creator A5034730864 @default.
• W2139388314 creator A5037651913 @default.
• W2139388314 creator A5040387567 @default.
• W2139388314 creator A5047441756 @default.
• W2139388314 creator A5050465932 @default.
• W2139388314 creator A5051869070 @default.
• W2139388314 creator A5053719183 @default.
• W2139388314 creator A5083505562 @default.
• W2139388314 creator A5091619722 @default.
• W2139388314 date "2010-02-15" @default.
• W2139388314 modified "2023-09-23" @default.
• W2139388314 title "Production of the Bsa Lantibiotic by Community-Acquired <i>Staphylococcus aureus</i> Strains" @default.
• W2139388314 cites W1523736689 @default.
• W2139388314 cites W1525080113 @default.
• W2139388314 cites W1548162677 @default.
• W2139388314 cites W1566759157 @default.
• W2139388314 cites W1571247924 @default.
• W2139388314 cites W1716867421 @default.
• W2139388314 cites W1848320945 @default.
• W2139388314 cites W1972439422 @default.
• W2139388314 cites W1977701349 @default.
• W2139388314 cites W1982226630 @default.
• W2139388314 cites W1991004031 @default.
• W2139388314 cites W1991634127 @default.
• W2139388314 cites W1995383789 @default.
• W2139388314 cites W1997298634 @default.
• W2139388314 cites W1997337616 @default.
• W2139388314 cites W2003940898 @default.
• W2139388314 cites W2005404275 @default.
• W2139388314 cites W2013048005 @default.
• W2139388314 cites W2013948180 @default.
• W2139388314 cites W2026220836 @default.
• W2139388314 cites W2026476282 @default.
• W2139388314 cites W2040034507 @default.
• W2139388314 cites W2044879187 @default.
• W2139388314 cites W2058752732 @default.
• W2139388314 cites W2061688904 @default.
• W2139388314 cites W2067348974 @default.
• W2139388314 cites W2067424225 @default.
• W2139388314 cites W2072763959 @default.
• W2139388314 cites W2089238458 @default.
• W2139388314 cites W2092543902 @default.
• W2139388314 cites W2096011773 @default.
• W2139388314 cites W2097509506 @default.
• W2139388314 cites W2099648162 @default.
• W2139388314 cites W2104379180 @default.
• W2139388314 cites W2104669367 @default.
• W2139388314 cites W2106192001 @default.
• W2139388314 cites W2106521502 @default.
• W2139388314 cites W2108643808 @default.
• W2139388314 cites W2110422600 @default.
• W2139388314 cites W2113651812 @default.
• W2139388314 cites W2115127793 @default.
• W2139388314 cites W2115991524 @default.
• W2139388314 cites W2118380403 @default.
• W2139388314 cites W2119628653 @default.
• W2139388314 cites W2120276613 @default.
• W2139388314 cites W2122710851 @default.
• W2139388314 cites W2124048377 @default.
• W2139388314 cites W2125698629 @default.
• W2139388314 cites W2133530652 @default.
• W2139388314 cites W2133682043 @default.
• W2139388314 cites W2134937983 @default.
• W2139388314 cites W2140903449 @default.
• W2139388314 cites W2143227116 @default.
• W2139388314 cites W2146325980 @default.
• W2139388314 cites W2148133809 @default.
• W2139388314 cites W2148414127 @default.
• W2139388314 cites W2154187341 @default.
• W2139388314 cites W2155864378 @default.
• W2139388314 cites W2158033863 @default.
• W2139388314 cites W2161137494 @default.
• W2139388314 cites W2161167549 @default.
• W2139388314 cites W2162031862 @default.
• W2139388314 cites W2163908033 @default.
• W2139388314 cites W2165465840 @default.
• W2139388314 cites W2171660616 @default.
• W2139388314 cites W2171998389 @default.
• W2139388314 cites W2172156934 @default.
• W2139388314 cites W2783981376 @default.
• W2139388314 cites W4232398336 @default.
• W2139388314 cites W4233351338 @default.
• W2139388314 cites W4246660111 @default.
• W2139388314 doi "https://doi.org/10.1128/jb.01375-09" @default.
• W2139388314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2812960" @default.
• W2139388314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20023032" @default.
• W2139388314 hasPublicationYear "2010" @default.
• W2139388314 type Work @default.
• W2139388314 sameAs 2139388314 @default.
• W2139388314 citedByCount "64" @default.
• W2139388314 countsByYear W21393883142012 @default.
• W2139388314 countsByYear W21393883142013 @default.

• next