FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139394837> ?p ?o ?g. }

• W2139394837 endingPage "908" @default.
• W2139394837 startingPage "896" @default.
• W2139394837 abstract "ABSTRACT Trypanosomes lack the transcriptional control characteristic of the majority of eukaryotes that is mediated by gene-specific promoters in a one-gene–one-promoter arrangement. Rather, their genomes are transcribed in large polycistrons with no obvious functional linkage. Posttranscriptional regulation of gene expression must thus play a larger role in these organisms. The eIF4E homolog TbEIF4E6 binds mRNA cap analogs in vitro and is part of a complex in vivo that may fulfill such a role. Knockdown of TbEIF4E6 tagged with protein A-tobacco etch virus protease cleavage site-protein C to approximately 15% of the normal expression level resulted in viable cells that displayed a set of phenotypes linked to detachment of the flagellum from the length of the cell body, if not outright flagellum loss. While these cells appeared and behaved as normal under stationary liquid culture conditions, standard centrifugation resulted in a marked increase in flagellar detachment. Furthermore, the ability of TbEIF4E6-depleted cells to engage in social motility was reduced. The TbEIF4E6 protein forms a cytosolic complex containing a triad of proteins, including the eIF4G homolog TbEIF4G5 and a hypothetical protein of 70.3 kDa, referred to as TbG5-IP. The TbG5-IP analysis revealed two domains with predicted secondary structures conserved in mRNA capping enzymes: nucleoside triphosphate hydrolase and guanylyltransferase. These complex members have the potential for RNA interaction, either via the 5′ cap structure for TbEIF4E6 and TbG5-IP or through RNA-binding domains in TbEIF4G5. The associated proteins provide a signpost for future studies to determine how this complex affects capped RNA molecules." @default.
• W2139394837 created "2016-06-24" @default.
• W2139394837 creator A5002739087 @default.
• W2139394837 creator A5005240902 @default.
• W2139394837 creator A5006474948 @default.
• W2139394837 creator A5013753659 @default.
• W2139394837 creator A5016942073 @default.
• W2139394837 creator A5022135015 @default.
• W2139394837 creator A5024442281 @default.
• W2139394837 creator A5037875924 @default.
• W2139394837 creator A5039704259 @default.
• W2139394837 creator A5061368593 @default.
• W2139394837 creator A5073423283 @default.
• W2139394837 creator A5082018128 @default.
• W2139394837 creator A5085621206 @default.
• W2139394837 creator A5090749236 @default.
• W2139394837 date "2014-07-01" @default.
• W2139394837 modified "2023-10-16" @default.
• W2139394837 title "Trypanosoma brucei Translation Initiation Factor Homolog EIF4E6 Forms a Tripartite Cytosolic Complex with EIF4G5 and a Capping Enzyme Homolog" @default.
• W2139394837 cites W149234214 @default.
• W2139394837 cites W1506886301 @default.
• W2139394837 cites W181468314 @default.
• W2139394837 cites W1907440158 @default.
• W2139394837 cites W1916206378 @default.
• W2139394837 cites W1919951605 @default.
• W2139394837 cites W1965894414 @default.
• W2139394837 cites W1965968267 @default.
• W2139394837 cites W1974939251 @default.
• W2139394837 cites W1980989389 @default.
• W2139394837 cites W1986478489 @default.
• W2139394837 cites W1988640094 @default.
• W2139394837 cites W1991769704 @default.
• W2139394837 cites W1992864884 @default.
• W2139394837 cites W1993287040 @default.
• W2139394837 cites W1999226149 @default.
• W2139394837 cites W2005024648 @default.
• W2139394837 cites W2005339253 @default.
• W2139394837 cites W2016469359 @default.
• W2139394837 cites W2025257323 @default.
• W2139394837 cites W2041383012 @default.
• W2139394837 cites W2047311318 @default.
• W2139394837 cites W2056960490 @default.
• W2139394837 cites W2057717261 @default.
• W2139394837 cites W2060259273 @default.
• W2139394837 cites W2060724961 @default.
• W2139394837 cites W2066316544 @default.
• W2139394837 cites W2067853554 @default.
• W2139394837 cites W2070761723 @default.
• W2139394837 cites W2071437890 @default.
• W2139394837 cites W2072042874 @default.
• W2139394837 cites W2073424121 @default.
• W2139394837 cites W2075511135 @default.
• W2139394837 cites W2076589041 @default.
• W2139394837 cites W2076784787 @default.
• W2139394837 cites W2082909867 @default.
• W2139394837 cites W2085101416 @default.
• W2139394837 cites W2086577386 @default.
• W2139394837 cites W2088834030 @default.
• W2139394837 cites W2092321887 @default.
• W2139394837 cites W2095842290 @default.
• W2139394837 cites W2111565312 @default.
• W2139394837 cites W2111874641 @default.
• W2139394837 cites W2111933838 @default.
• W2139394837 cites W2114175350 @default.
• W2139394837 cites W2120194124 @default.
• W2139394837 cites W2122261141 @default.
• W2139394837 cites W2123139638 @default.
• W2139394837 cites W2124876345 @default.
• W2139394837 cites W2127933750 @default.
• W2139394837 cites W2131373844 @default.
• W2139394837 cites W2136711098 @default.
• W2139394837 cites W2137063826 @default.
• W2139394837 cites W2142528445 @default.
• W2139394837 cites W2145284274 @default.
• W2139394837 cites W2146981677 @default.
• W2139394837 cites W2150989851 @default.
• W2139394837 cites W2152013222 @default.
• W2139394837 cites W2152645648 @default.
• W2139394837 cites W2153132589 @default.
• W2139394837 cites W2157084214 @default.
• W2139394837 cites W2157497892 @default.
• W2139394837 cites W2157974457 @default.
• W2139394837 cites W2158427156 @default.
• W2139394837 cites W2163273515 @default.
• W2139394837 cites W2169727429 @default.
• W2139394837 cites W2170213694 @default.
• W2139394837 cites W2170262693 @default.
• W2139394837 cites W2189532371 @default.
• W2139394837 cites W2789319786 @default.
• W2139394837 doi "https://doi.org/10.1128/ec.00071-14" @default.
• W2139394837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4135740" @default.
• W2139394837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24839125" @default.
• W2139394837 hasPublicationYear "2014" @default.
• W2139394837 type Work @default.
• W2139394837 sameAs 2139394837 @default.
• W2139394837 citedByCount "40" @default.
• W2139394837 countsByYear W21393948372014 @default.
• W2139394837 countsByYear W21393948372015 @default.

• next