Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139401457> ?p ?o ?g. }
- W2139401457 endingPage "678" @default.
- W2139401457 startingPage "673" @default.
- W2139401457 abstract "Activation regulates the responsiveness of G-protein-coupled receptors (GPCRs) on T cells, and modifications in the activity of GPCRs characterize lymphocytes from some immune disorders such as multiple sclerosis (MS) and rheumatoid arthritis (RA). Some lines of evidence suggest that such an effect is connected with the altered expression of some GPCRs regulatory proteins. Herein we demonstrate that phitoemagglutinin (PHA)-induced activation leads to differential expression of G-protein-coupled receptor kinase (GRK) 2, GRK3, beta-arrestin-1, regulators of G-protein signalling (RGS) 2, and RGS16 and decreases responsiveness of mononuclear leukocytes (MNL) to the beta-adrenergic agonist isoproterenol. Interferon beta-1a (IFN beta-1a), which is known to ameliorate the course of MS, counteracts the activation-induced effects on the expression of these GPCR regulatory proteins in MNL. Furthermore, IFN beta-1a quenches the effects of PHA on the isoproterenol-induced accumulation of cyclic AMP (cAMP). We suggest that regulation of GPCRs responsiveness may be a relevant property of IFN beta-1a in MS." @default.
- W2139401457 created "2016-06-24" @default.
- W2139401457 creator A5006756584 @default.
- W2139401457 creator A5009537758 @default.
- W2139401457 creator A5023725739 @default.
- W2139401457 creator A5030439171 @default.
- W2139401457 creator A5034686679 @default.
- W2139401457 creator A5037169581 @default.
- W2139401457 creator A5044214963 @default.
- W2139401457 creator A5049603619 @default.
- W2139401457 creator A5052663815 @default.
- W2139401457 creator A5070897359 @default.
- W2139401457 creator A5076090392 @default.
- W2139401457 date "2002-08-01" @default.
- W2139401457 modified "2023-10-02" @default.
- W2139401457 title "Interferon beta-1a counteracts effects of activation on the expression of G-protein-coupled receptor kinases 2 and 3, β-arrestin-1, and regulators of G-protein signalling 2 and 16 in human mononuclear leukocytes" @default.
- W2139401457 cites W1504365126 @default.
- W2139401457 cites W1514710040 @default.
- W2139401457 cites W1519962349 @default.
- W2139401457 cites W1548605804 @default.
- W2139401457 cites W1550545417 @default.
- W2139401457 cites W1602986951 @default.
- W2139401457 cites W1900616108 @default.
- W2139401457 cites W1929814565 @default.
- W2139401457 cites W1945832201 @default.
- W2139401457 cites W1966339678 @default.
- W2139401457 cites W1970820951 @default.
- W2139401457 cites W1974754757 @default.
- W2139401457 cites W1976537218 @default.
- W2139401457 cites W1989817592 @default.
- W2139401457 cites W2000599573 @default.
- W2139401457 cites W2006718599 @default.
- W2139401457 cites W2013581305 @default.
- W2139401457 cites W2024061399 @default.
- W2139401457 cites W2032221545 @default.
- W2139401457 cites W2038312257 @default.
- W2139401457 cites W2050141745 @default.
- W2139401457 cites W2051371077 @default.
- W2139401457 cites W2060109120 @default.
- W2139401457 cites W2063375252 @default.
- W2139401457 cites W2066281156 @default.
- W2139401457 cites W2081294643 @default.
- W2139401457 cites W2086196933 @default.
- W2139401457 cites W2116949924 @default.
- W2139401457 cites W2117687565 @default.
- W2139401457 cites W2124795017 @default.
- W2139401457 cites W2126207219 @default.
- W2139401457 cites W2126288946 @default.
- W2139401457 cites W2143166807 @default.
- W2139401457 cites W2149543002 @default.
- W2139401457 cites W2171944465 @default.
- W2139401457 cites W2398478012 @default.
- W2139401457 doi "https://doi.org/10.1016/s0898-6568(02)00011-6" @default.
- W2139401457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12020767" @default.
- W2139401457 hasPublicationYear "2002" @default.
- W2139401457 type Work @default.
- W2139401457 sameAs 2139401457 @default.
- W2139401457 citedByCount "19" @default.
- W2139401457 countsByYear W21394014572012 @default.
- W2139401457 countsByYear W21394014572013 @default.
- W2139401457 countsByYear W21394014572014 @default.
- W2139401457 countsByYear W21394014572015 @default.
- W2139401457 countsByYear W21394014572020 @default.
- W2139401457 crossrefType "journal-article" @default.
- W2139401457 hasAuthorship W2139401457A5006756584 @default.
- W2139401457 hasAuthorship W2139401457A5009537758 @default.
- W2139401457 hasAuthorship W2139401457A5023725739 @default.
- W2139401457 hasAuthorship W2139401457A5030439171 @default.
- W2139401457 hasAuthorship W2139401457A5034686679 @default.
- W2139401457 hasAuthorship W2139401457A5037169581 @default.
- W2139401457 hasAuthorship W2139401457A5044214963 @default.
- W2139401457 hasAuthorship W2139401457A5049603619 @default.
- W2139401457 hasAuthorship W2139401457A5052663815 @default.
- W2139401457 hasAuthorship W2139401457A5070897359 @default.
- W2139401457 hasAuthorship W2139401457A5076090392 @default.
- W2139401457 hasConcept C135285700 @default.
- W2139401457 hasConcept C139407321 @default.
- W2139401457 hasConcept C170493617 @default.
- W2139401457 hasConcept C176303035 @default.
- W2139401457 hasConcept C184235292 @default.
- W2139401457 hasConcept C185592680 @default.
- W2139401457 hasConcept C2777503648 @default.
- W2139401457 hasConcept C2778938600 @default.
- W2139401457 hasConcept C33235085 @default.
- W2139401457 hasConcept C55493867 @default.
- W2139401457 hasConcept C62478195 @default.
- W2139401457 hasConcept C78976303 @default.
- W2139401457 hasConcept C80631254 @default.
- W2139401457 hasConcept C86803240 @default.
- W2139401457 hasConcept C95444343 @default.
- W2139401457 hasConcept C97029542 @default.
- W2139401457 hasConceptScore W2139401457C135285700 @default.
- W2139401457 hasConceptScore W2139401457C139407321 @default.
- W2139401457 hasConceptScore W2139401457C170493617 @default.
- W2139401457 hasConceptScore W2139401457C176303035 @default.
- W2139401457 hasConceptScore W2139401457C184235292 @default.
- W2139401457 hasConceptScore W2139401457C185592680 @default.
- W2139401457 hasConceptScore W2139401457C2777503648 @default.