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- W2139435748 endingPage "a005538" @default.
- W2139435748 startingPage "a005538" @default.
- W2139435748 abstract "The T cell receptor (TCR) is responsible for discriminating between self- and foreign-derived peptides, translating minute differences in amino-acid sequence into large differences in response. Because of the great variability in the TCR and its ligands, activation of T cells by foreign peptides is a quantitative process, dependent on a mix of upstream signals and downstream integration. Accordingly, quantitative data and computational models have shed light on many important aspects of this process: molecular noise in ligand recognition, spatial dynamics in T cell-APC (antigen presenting cell) interactions, graded versus all-or-none decision making by the TCR apparatus, mechanisms of peptide antagonism and synergism, and the tunability and robustness of activation thresholds. Though diverse in their formalism, these studies together paint a picture of how modeling has shaped and will continue to shape understanding of T cell immunobiology." @default.
- W2139435748 created "2016-06-24" @default.
- W2139435748 creator A5023421069 @default.
- W2139435748 creator A5033455343 @default.
- W2139435748 creator A5088777789 @default.
- W2139435748 date "2010-05-05" @default.
- W2139435748 modified "2023-10-16" @default.
- W2139435748 title "Perspectives for Computer Modeling in the Study of T Cell Activation" @default.
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