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• W2139440265 abstract "Caprin-1 is a ubiquitously expressed, well-conserved cytoplasmic phosphoprotein that is needed for normal progression through the G1-S phase of the cell cycle and occurs in postsynaptic granules in dendrites of neurons. We demonstrate that Caprin-1 colocalizes with RasGAP SH3 domain binding protein-1 (G3BP-1) in cytoplasmic RNA granules associated with microtubules and concentrated in the leading and trailing edge of migrating cells. Caprin-1 exhibits a highly conserved motif, F(M/I/L)Q(D/E)Sx(I/L)D that binds to the NTF-2-like domain of G3BP-1. The carboxy-terminal region of Caprin-1 selectively bound mRNA for c-Myc or cyclin D2, this binding being diminished by mutation of the three RGG motifs and abolished by deletion of the RGG-rich region. Overexpression of Caprin-1 induced phosphorylation of eukaryotic translation initiation factor 2α (eIF-2α) through a mechanism that depended on its ability to bind mRNA, resulting in global inhibition of protein synthesis. However, cells lacking Caprin-1 exhibited no changes in global rates of protein synthesis, suggesting that physiologically, the effects of Caprin-1 on translation were limited to restricted subsets of mRNAs. Overexpression of Caprin-1 induced the formation of cytoplasmic stress granules (SG). Its ability to bind RNA was required to induce SG formation but not necessarily its ability to enter SG. The ability of Caprin-1 or G3BP-1 to induce SG formation or enter them did not depend on their association with each other. The Caprin-1/G3BP-1 complex is likely to regulate the transport and translation of mRNAs of proteins involved with synaptic plasticity in neurons and cellular proliferation and migration in multiple cell types." @default.
• W2139440265 created "2016-06-24" @default.
• W2139440265 creator A5009219737 @default.
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• W2139440265 date "2007-03-01" @default.
• W2139440265 modified "2023-10-16" @default.
• W2139440265 title "Distinct Structural Features ofCaprin-1 Mediate Its Interaction with G3BP-1 and Its Induction of Phosphorylation of Eukaryotic Translation InitiationFactor 2<i>α</i>, Entry to Cytoplasmic Stress Granules, and Selective Interaction with a Subset of mRNAs" @default.
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• W2139440265 doi "https://doi.org/10.1128/mcb.02300-06" @default.
• W2139440265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1820512" @default.
• W2139440265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17210633" @default.
• W2139440265 hasPublicationYear "2007" @default.
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