FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139454008> ?p ?o ?g. }

• W2139454008 abstract "This study examined the protective effects of total saponins from Ornithogalum saundersiae (Liliaceae) on D-galactosamine (D-GalN) and lipopolysaccharide (LPS)-induced fulminant hepatic failure.Total saponins of Ornithogalum saundersiae (Liliaceae) (OC) were prepared with ethyl alcohol extract from bulbs of the plant. Mice were given an intraperitoneal injection of D-GalN (700 mg/kg)/LPS (10 μg/kg). OC (100 mg/kg, 200 mg/kg and 300 mg/kg) was administered orally for 3 days continuously, and at the last day at 1 h before the D-GalN/LPS injection. Mice were sacrificed at 8 h after the D-GalN/LPS injection. The liver injury was assessed biochemically, investigating aspartate aminotransferase (AST), alanine aminotransferase (ALT), malondialdehyde (MDA), glutathione (GSH) activities, and the expressions of caspase-3 and hypoxia inducible factor-1α (HIF-1α) as well. Tumor necrosis factor (TNF-α) content was measured after D-GalN/LPS induced 1 h by ELISA assay. The survival rates after application of OC in 24 h also were observed.D-GalN/LPS increased the serum aminotransferase levels and lipid peroxidation, while decreased the reduced glutathione level. The pretreatment with OC attenuated these changes in a dose-dependent manner. Elevation of TNF-α level and activation of caspase-3, HIF-1α were observed in the D-GalN/LPS group, which was attenuated by OC. The survival rate of the OC groups was significantly higher than that of the D-GalN/LPS group.Protection afforded by OC against D-GalN/LPS-induced fulminant hepatic failure is the result of reduced oxidative stress, inhibited expression of caspase-3, HIF-1α, and anti-apoptotic activity." @default.
• W2139454008 created "2016-06-24" @default.
• W2139454008 creator A5002319743 @default.
• W2139454008 creator A5009824978 @default.
• W2139454008 creator A5013754633 @default.
• W2139454008 creator A5032830955 @default.
• W2139454008 creator A5042032289 @default.
• W2139454008 creator A5089869894 @default.
• W2139454008 date "2010-11-01" @default.
• W2139454008 modified "2023-09-25" @default.
• W2139454008 title "The protective effects of total saponins from Ornithogalum saundersiae (Liliaceae) on acute hepatic failure induced by lipopolysaccharide and d-galactosamine in mice" @default.
• W2139454008 cites W1971839518 @default.
• W2139454008 cites W1977596178 @default.
• W2139454008 cites W1980795039 @default.
• W2139454008 cites W1983362110 @default.
• W2139454008 cites W1987032520 @default.
• W2139454008 cites W1996345068 @default.
• W2139454008 cites W1997275067 @default.
• W2139454008 cites W2021760949 @default.
• W2139454008 cites W2030634993 @default.
• W2139454008 cites W2034782935 @default.
• W2139454008 cites W2055902411 @default.
• W2139454008 cites W2078394995 @default.
• W2139454008 cites W2089474349 @default.
• W2139454008 cites W2106704952 @default.
• W2139454008 cites W2113555800 @default.
• W2139454008 cites W2460937798 @default.
• W2139454008 cites W384075993 @default.
• W2139454008 cites W4234288885 @default.
• W2139454008 cites W4293282159 @default.
• W2139454008 doi "https://doi.org/10.1016/j.jep.2010.08.025" @default.
• W2139454008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20713143" @default.
• W2139454008 hasPublicationYear "2010" @default.
• W2139454008 type Work @default.
• W2139454008 sameAs 2139454008 @default.
• W2139454008 citedByCount "25" @default.
• W2139454008 countsByYear W21394540082012 @default.
• W2139454008 countsByYear W21394540082013 @default.
• W2139454008 countsByYear W21394540082014 @default.
• W2139454008 countsByYear W21394540082015 @default.
• W2139454008 countsByYear W21394540082016 @default.
• W2139454008 countsByYear W21394540082017 @default.
• W2139454008 countsByYear W21394540082018 @default.
• W2139454008 countsByYear W21394540082019 @default.
• W2139454008 countsByYear W21394540082020 @default.
• W2139454008 countsByYear W21394540082022 @default.
• W2139454008 crossrefType "journal-article" @default.
• W2139454008 hasAuthorship W2139454008A5002319743 @default.
• W2139454008 hasAuthorship W2139454008A5009824978 @default.
• W2139454008 hasAuthorship W2139454008A5013754633 @default.
• W2139454008 hasAuthorship W2139454008A5032830955 @default.
• W2139454008 hasAuthorship W2139454008A5042032289 @default.
• W2139454008 hasAuthorship W2139454008A5089869894 @default.
• W2139454008 hasConcept C126322002 @default.
• W2139454008 hasConcept C134018914 @default.
• W2139454008 hasConcept C17991360 @default.
• W2139454008 hasConcept C181199279 @default.
• W2139454008 hasConcept C185592680 @default.
• W2139454008 hasConcept C2776151105 @default.
• W2139454008 hasConcept C2778401633 @default.
• W2139454008 hasConcept C2778754761 @default.
• W2139454008 hasConcept C2779609443 @default.
• W2139454008 hasConcept C2780159080 @default.
• W2139454008 hasConcept C2780829032 @default.
• W2139454008 hasConcept C2911091166 @default.
• W2139454008 hasConcept C2911118192 @default.
• W2139454008 hasConcept C538909803 @default.
• W2139454008 hasConcept C55493867 @default.
• W2139454008 hasConcept C71924100 @default.
• W2139454008 hasConcept C98274493 @default.
• W2139454008 hasConceptScore W2139454008C126322002 @default.
• W2139454008 hasConceptScore W2139454008C134018914 @default.
• W2139454008 hasConceptScore W2139454008C17991360 @default.
• W2139454008 hasConceptScore W2139454008C181199279 @default.
• W2139454008 hasConceptScore W2139454008C185592680 @default.
• W2139454008 hasConceptScore W2139454008C2776151105 @default.
• W2139454008 hasConceptScore W2139454008C2778401633 @default.
• W2139454008 hasConceptScore W2139454008C2778754761 @default.
• W2139454008 hasConceptScore W2139454008C2779609443 @default.
• W2139454008 hasConceptScore W2139454008C2780159080 @default.
• W2139454008 hasConceptScore W2139454008C2780829032 @default.
• W2139454008 hasConceptScore W2139454008C2911091166 @default.
• W2139454008 hasConceptScore W2139454008C2911118192 @default.
• W2139454008 hasConceptScore W2139454008C538909803 @default.
• W2139454008 hasConceptScore W2139454008C55493867 @default.
• W2139454008 hasConceptScore W2139454008C71924100 @default.
• W2139454008 hasConceptScore W2139454008C98274493 @default.
• W2139454008 hasLocation W21394540081 @default.
• W2139454008 hasLocation W21394540082 @default.
• W2139454008 hasOpenAccess W2139454008 @default.
• W2139454008 hasPrimaryLocation W21394540081 @default.
• W2139454008 hasRelatedWork W1509676400 @default.
• W2139454008 hasRelatedWork W1970438098 @default.
• W2139454008 hasRelatedWork W1977367026 @default.
• W2139454008 hasRelatedWork W2004599262 @default.
• W2139454008 hasRelatedWork W2023732561 @default.
• W2139454008 hasRelatedWork W2029280678 @default.
• W2139454008 hasRelatedWork W2050280213 @default.
• W2139454008 hasRelatedWork W2051382767 @default.
• W2139454008 hasRelatedWork W2055869203 @default.

• next