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- W2139480319 abstract "Testosterone (T) has repeatedly been shown to have anxiolytic properties in rodents, but findings in primates are more mixed. To examine the effects of exogenous T on anxiety, we tested pharmacologically-castrated adult male rhesus monkeys in a modified version of the Human Intruder Paradigm, which measured defensive responses to an unfamiliar human staring directly at them for 2 min. Monkeys were tested at 2 week intervals during 4 experimental conditions lasting 4 weeks each: at baseline, during treatment with the gonadotropin releasing hormone (GnRH) agonist leuprolide acetate (200 μg/kg; Lupron phase), during treatment with Lupron+T enanthate (TE, 5 mg/kg; TE phase) and during treatment with Lupron+oil vehicle (oil phase). We found that the number of anxious behaviors was lower during periods of low T (Lupron only and Lupron+oil phases) than during the Lupron+TE phase. No change in pacing or watching behavior was observed. Thus, in contrast to rodent data, we found no evidence for anxiolytic properties of T in male rhesus monkeys. Rather, T supplementation restored baseline levels of anxiety in Lupron-treated monkeys. These discrepant findings may be best explained by the low levels of gonadotropins achieved by the GnRH agonist. We suggest that Lupron-induced luteinizing hormone (LH) suppression reduced anxiety and that this effect was abolished by T administration. This interpretation is consistent with the view that T increases emotional reactivity to a potential threat and facilitates adaptive arousal response in face of immediate social challenge." @default.
- W2139480319 created "2016-06-24" @default.
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- W2139480319 creator A5046366503 @default.
- W2139480319 creator A5087666601 @default.
- W2139480319 date "2013-03-01" @default.
- W2139480319 modified "2023-10-01" @default.
- W2139480319 title "Testosterone modulation of anxiety in gonadally-suppressed male rhesus monkeys: A role for gonadotropins?" @default.
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- W2139480319 doi "https://doi.org/10.1016/j.pbb.2013.01.004" @default.
- W2139480319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23333155" @default.
- W2139480319 hasPublicationYear "2013" @default.
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