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- W2139523610 endingPage "1529" @default.
- W2139523610 startingPage "1515" @default.
- W2139523610 abstract "Many oncogenes, growth factor, cytokine and cell-cycle genes are regulated post-transcriptionally. The major mechanism is by controlling the rate of mRNA turnover for transcripts bearing destabilizing cis-elements. To date, only a handful of regulatory factors have been identified that appear to control a large pool of target mRNAs, suggesting that a slight perturbation in the control mechanism may generate wide-ranging effects that could contribute to the development of a complex disorder such as cancer. In support of this view, mRNA turnover responds to signalling pathways that are often overactive in cancer, suggesting a post-transcriptional component in addition to the well-recognised transcriptional aspect of oncogenesis. Here the authors review examples of deregulated post-transcriptional control in oncogenesis, discuss post-transcriptionally regulated transcripts of oncologic significance, and consider the key role of signalling pathways in linking both processes and as an enticing therapeutic prospect." @default.
- W2139523610 created "2016-06-24" @default.
- W2139523610 creator A5037940437 @default.
- W2139523610 creator A5089700251 @default.
- W2139523610 date "2007-10-01" @default.
- W2139523610 modified "2023-10-03" @default.
- W2139523610 title "mRNA stability and cancer: an emerging link?" @default.
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