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• W2139541353 abstract "This editorial refers to ‘Human autopsy study of drug-eluting stents restenosis: histomorphological predictors and neointimal characteristics’[†][1], by M. Nakano et al. , on page 3304 The advent of drug-eluting stents (DES) has revolutionized percutaneous coronary interventions (PCIs) by combining the properties of radial vessel support with the possibility of local drug delivery. While in-stent restenosis had previously been a major problem, occurring in 20–40% of patients with early-generation bare metal stents (BMS),1,2 it has been impressively reduced by the concept of DES. Studies have not only proven a reduction of target vessel revascularization by the use of DES, but have also demonstrated their safety and efficacy beyond prevention of restenosis. Therefore, DES implantation has been further transferred into high-risk populations and yielded promising results in diabetic patients, in-stent restenosis, and multivessel disease. Yet, the concept of DES was questioned by data presented during the annual congress of the European Society of Cardiology in Barcelona 2006 suggesting increased rates of stent thrombosis after DES implantation, also known as the ‘Barcelona fire storm’.3–5 However, more recent data during the last 5 years have proven the safety of DES and dispelled irrational fears.6,7 Subsequent generations of DES with improved properties of the platform have been developed, e.g. smaller strut thickness, optimized deliverability, as well as improved drug delivery, resulting in improved safety.8–11Nevertheless, even DES implantation entails the less frequent, but clinically important problems of restenosis and chronic occlusion, which interventional cardiologists are still facing in their current daily routine. These two events are often connected with certain patient characteristics and lesion types ( Figure 1 ), but there is still uncertainty about their exact mechanisms or predictors. Is it the type of drug the metallic stent is eluting? Is it the property of … [1]: #fn-2" @default.
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• W2139541353 date "2013-10-02" @default.
• W2139541353 modified "2023-09-25" @default.
• W2139541353 title "Coronary stent restenosis and occlusion: messages from the dead for the living" @default.
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• W2139541353 doi "https://doi.org/10.1093/eurheartj/eht300" @default.
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