FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139556561> ?p ?o ?g. }

• W2139556561 endingPage "109" @default.
• W2139556561 startingPage "103" @default.
• W2139556561 abstract "Hydrogen sulphide (H2S) exerts several anti-inflammatory effects, accelerates the healing of experimental gastric ulcers, and can stimulate intestinal secretion. Little is known about H2S synthesis in the gastrointestinal tract. The aim of this study was to characterize H2S synthesis throughout the gastrointestinal tract.H2S synthesis in various gastrointestinal tissues of rats and mice was determined. The effects and selectivity of inhibitors of two key enzymes for H2S synthesis, cystathionine-gamma-lyase and cystathionine-beta-synthase, were examined. Cystathionine-gamma-lyase and cystathionine-beta-synthase expression was evaluated by Western blotting and immunohistochemistry. Cystathionine-gamma-lyase and cystathionine-beta-synthase expression in biopsies of human colon was also examined.H2S synthesis was variable throughout the gastrointestinal tract in parallel with variations in cystathionine-gamma-lyase and cystathionine-beta-synthase expression. The efficacy of cystathionine-beta-synthase and cystathionine-gamma-lyase inhibitors to reduce H2S synthesis in these tissues was also variable. Cystathionine-beta-synthase is the predominant source of H2S synthesis in the colon of rodents. Cystathionine-gamma-lyase and cystathionine-beta-synthase were also expressed in healthy human colon biopsies.The capacity for H2S synthesis varies throughout the rodent gastrointestinal tract, as does the distribution and contribution of the two key enzymes. Investigation of additional enzymatic sources of H2S and the development of more selective inhibitors are suggested." @default.
• W2139556561 created "2016-06-24" @default.
• W2139556561 creator A5018017904 @default.
• W2139556561 creator A5025589681 @default.
• W2139556561 creator A5027937626 @default.
• W2139556561 creator A5070586591 @default.
• W2139556561 creator A5084326812 @default.
• W2139556561 creator A5086633019 @default.
• W2139556561 date "2010-02-01" @default.
• W2139556561 modified "2023-10-01" @default.
• W2139556561 title "Hydrogen sulphide synthesis in the rat and mouse gastrointestinal tract" @default.
• W2139556561 cites W1595268754 @default.
• W2139556561 cites W1764016564 @default.
• W2139556561 cites W1879953056 @default.
• W2139556561 cites W1888068317 @default.
• W2139556561 cites W1972016174 @default.
• W2139556561 cites W1973592190 @default.
• W2139556561 cites W1991824136 @default.
• W2139556561 cites W2000707489 @default.
• W2139556561 cites W2003588479 @default.
• W2139556561 cites W2004648970 @default.
• W2139556561 cites W2005616472 @default.
• W2139556561 cites W2015407072 @default.
• W2139556561 cites W2016101932 @default.
• W2139556561 cites W2017161829 @default.
• W2139556561 cites W2018768907 @default.
• W2139556561 cites W2021697305 @default.
• W2139556561 cites W2025905719 @default.
• W2139556561 cites W2026465800 @default.
• W2139556561 cites W2028606217 @default.
• W2139556561 cites W2032861502 @default.
• W2139556561 cites W2035996289 @default.
• W2139556561 cites W2054064167 @default.
• W2139556561 cites W2056036527 @default.
• W2139556561 cites W2063325639 @default.
• W2139556561 cites W2068065773 @default.
• W2139556561 cites W2069161855 @default.
• W2139556561 cites W2074149437 @default.
• W2139556561 cites W2081447694 @default.
• W2139556561 cites W2094928959 @default.
• W2139556561 cites W2099069677 @default.
• W2139556561 cites W2119739111 @default.
• W2139556561 cites W2122438668 @default.
• W2139556561 cites W2139466474 @default.
• W2139556561 cites W2141610173 @default.
• W2139556561 cites W2156615759 @default.
• W2139556561 cites W2168990431 @default.
• W2139556561 cites W2169746496 @default.
• W2139556561 cites W2169886283 @default.
• W2139556561 doi "https://doi.org/10.1016/j.dld.2009.05.016" @default.
• W2139556561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19570733" @default.
• W2139556561 hasPublicationYear "2010" @default.
• W2139556561 type Work @default.
• W2139556561 sameAs 2139556561 @default.
• W2139556561 citedByCount "91" @default.
• W2139556561 countsByYear W21395565612012 @default.
• W2139556561 countsByYear W21395565612013 @default.
• W2139556561 countsByYear W21395565612014 @default.
• W2139556561 countsByYear W21395565612015 @default.
• W2139556561 countsByYear W21395565612016 @default.
• W2139556561 countsByYear W21395565612017 @default.
• W2139556561 countsByYear W21395565612018 @default.
• W2139556561 countsByYear W21395565612019 @default.
• W2139556561 countsByYear W21395565612020 @default.
• W2139556561 countsByYear W21395565612021 @default.
• W2139556561 countsByYear W21395565612022 @default.
• W2139556561 countsByYear W21395565612023 @default.
• W2139556561 crossrefType "journal-article" @default.
• W2139556561 hasAuthorship W2139556561A5018017904 @default.
• W2139556561 hasAuthorship W2139556561A5025589681 @default.
• W2139556561 hasAuthorship W2139556561A5027937626 @default.
• W2139556561 hasAuthorship W2139556561A5070586591 @default.
• W2139556561 hasAuthorship W2139556561A5084326812 @default.
• W2139556561 hasAuthorship W2139556561A5086633019 @default.
• W2139556561 hasConcept C16525657 @default.
• W2139556561 hasConcept C181199279 @default.
• W2139556561 hasConcept C187566844 @default.
• W2139556561 hasConcept C2777269803 @default.
• W2139556561 hasConcept C2779201268 @default.
• W2139556561 hasConcept C2780512811 @default.
• W2139556561 hasConcept C55493867 @default.
• W2139556561 hasConcept C71924100 @default.
• W2139556561 hasConcept C86803240 @default.
• W2139556561 hasConceptScore W2139556561C16525657 @default.
• W2139556561 hasConceptScore W2139556561C181199279 @default.
• W2139556561 hasConceptScore W2139556561C187566844 @default.
• W2139556561 hasConceptScore W2139556561C2777269803 @default.
• W2139556561 hasConceptScore W2139556561C2779201268 @default.
• W2139556561 hasConceptScore W2139556561C2780512811 @default.
• W2139556561 hasConceptScore W2139556561C55493867 @default.
• W2139556561 hasConceptScore W2139556561C71924100 @default.
• W2139556561 hasConceptScore W2139556561C86803240 @default.
• W2139556561 hasIssue "2" @default.
• W2139556561 hasLocation W21395565611 @default.
• W2139556561 hasLocation W21395565612 @default.
• W2139556561 hasOpenAccess W2139556561 @default.
• W2139556561 hasPrimaryLocation W21395565611 @default.
• W2139556561 hasRelatedWork W1755546657 @default.

• next