Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139603753> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2139603753 abstract "Recently, we have demonstrated that plant DNA virus replication could be inhibited in Arabidopsis thaliana by using an artificial zinc-finger protein (AZP) and created AZP-based transgenic A. thaliana resistant to DNA virus infection. Here we apply the AZP technology to inhibition of replication of a mammalian DNA virus, human papillomavirus (HPV) type 18. Two AZPs, designated AZP(HPV)-1 and AZP(HPV)-2, were designed to block binding of the HPV-18 E2 replication protein to the replication origin. Both the designed AZPs had much higher affinities towards the replication origin than did the E2 protein, and efficiently blocked E2 binding in vitro. In transient replication assays, both AZPs inhibited the viral DNA replication: AZP(HPV)-2, especially, reduced the replication level to approximately 10%. Thus, it was demonstrated that the AZP technology could be applied not only to plant DNA viruses, but also to mammalian DNA viruses." @default.
- W2139603753 created "2016-06-24" @default.
- W2139603753 creator A5004954650 @default.
- W2139603753 creator A5025523160 @default.
- W2139603753 creator A5041823290 @default.
- W2139603753 creator A5051811928 @default.
- W2139603753 creator A5064234223 @default.
- W2139603753 creator A5070728503 @default.
- W2139603753 creator A5079112300 @default.
- W2139603753 date "2006-11-01" @default.
- W2139603753 modified "2023-10-06" @default.
- W2139603753 title "Application of artificial zinc-finger proteins to inhibition of DNA replication of human papillomavirus" @default.
- W2139603753 doi "https://doi.org/10.1093/nass/nrl156" @default.
- W2139603753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17150943" @default.
- W2139603753 hasPublicationYear "2006" @default.
- W2139603753 type Work @default.
- W2139603753 sameAs 2139603753 @default.
- W2139603753 citedByCount "1" @default.
- W2139603753 countsByYear W21396037532018 @default.
- W2139603753 crossrefType "journal-article" @default.
- W2139603753 hasAuthorship W2139603753A5004954650 @default.
- W2139603753 hasAuthorship W2139603753A5025523160 @default.
- W2139603753 hasAuthorship W2139603753A5041823290 @default.
- W2139603753 hasAuthorship W2139603753A5051811928 @default.
- W2139603753 hasAuthorship W2139603753A5064234223 @default.
- W2139603753 hasAuthorship W2139603753A5070728503 @default.
- W2139603753 hasAuthorship W2139603753A5079112300 @default.
- W2139603753 hasBestOaLocation W21396037531 @default.
- W2139603753 hasConcept C104317684 @default.
- W2139603753 hasConcept C104690221 @default.
- W2139603753 hasConcept C113271649 @default.
- W2139603753 hasConcept C140704245 @default.
- W2139603753 hasConcept C153911025 @default.
- W2139603753 hasConcept C159047783 @default.
- W2139603753 hasConcept C175193931 @default.
- W2139603753 hasConcept C188036394 @default.
- W2139603753 hasConcept C24284526 @default.
- W2139603753 hasConcept C2522874641 @default.
- W2139603753 hasConcept C54355233 @default.
- W2139603753 hasConcept C552990157 @default.
- W2139603753 hasConcept C73573662 @default.
- W2139603753 hasConcept C7452308 @default.
- W2139603753 hasConcept C86339819 @default.
- W2139603753 hasConcept C86803240 @default.
- W2139603753 hasConcept C94966510 @default.
- W2139603753 hasConcept C95444343 @default.
- W2139603753 hasConcept C98086919 @default.
- W2139603753 hasConceptScore W2139603753C104317684 @default.
- W2139603753 hasConceptScore W2139603753C104690221 @default.
- W2139603753 hasConceptScore W2139603753C113271649 @default.
- W2139603753 hasConceptScore W2139603753C140704245 @default.
- W2139603753 hasConceptScore W2139603753C153911025 @default.
- W2139603753 hasConceptScore W2139603753C159047783 @default.
- W2139603753 hasConceptScore W2139603753C175193931 @default.
- W2139603753 hasConceptScore W2139603753C188036394 @default.
- W2139603753 hasConceptScore W2139603753C24284526 @default.
- W2139603753 hasConceptScore W2139603753C2522874641 @default.
- W2139603753 hasConceptScore W2139603753C54355233 @default.
- W2139603753 hasConceptScore W2139603753C552990157 @default.
- W2139603753 hasConceptScore W2139603753C73573662 @default.
- W2139603753 hasConceptScore W2139603753C7452308 @default.
- W2139603753 hasConceptScore W2139603753C86339819 @default.
- W2139603753 hasConceptScore W2139603753C86803240 @default.
- W2139603753 hasConceptScore W2139603753C94966510 @default.
- W2139603753 hasConceptScore W2139603753C95444343 @default.
- W2139603753 hasConceptScore W2139603753C98086919 @default.
- W2139603753 hasLocation W21396037531 @default.
- W2139603753 hasLocation W21396037532 @default.
- W2139603753 hasOpenAccess W2139603753 @default.
- W2139603753 hasPrimaryLocation W21396037531 @default.
- W2139603753 hasRelatedWork W2017802952 @default.
- W2139603753 hasRelatedWork W2036876978 @default.
- W2139603753 hasRelatedWork W2038164592 @default.
- W2139603753 hasRelatedWork W2056108746 @default.
- W2139603753 hasRelatedWork W2104459561 @default.
- W2139603753 hasRelatedWork W2112532851 @default.
- W2139603753 hasRelatedWork W2117448007 @default.
- W2139603753 hasRelatedWork W2139603753 @default.
- W2139603753 hasRelatedWork W2145664689 @default.
- W2139603753 hasRelatedWork W2164112459 @default.
- W2139603753 isParatext "false" @default.
- W2139603753 isRetracted "false" @default.
- W2139603753 magId "2139603753" @default.
- W2139603753 workType "article" @default.