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- W2139604805 abstract "Interleukin (IL)-4 and IL-13 are key factors in the pathogenesis of bronchopulmonary mycosis induced in mice by infection with Cryptococcus neoformans. Both cytokines use the IL-4 receptor α-chain (IL-4Rα). In this study, we investigated the role played by IL-4Rα expression in susceptibility to pulmonary C. neoformans infection. IL-4Rα−/− mice were extremely resistant. To characterize the effect of IL-4Rα expression level on disease outcome, we generated IL-4Rα+/− first-generation (F1) mice. IL-4Rα+/− mice showed intermediate levels of IL-4Rα expression, in contrast to higher levels in wild-type mice and no expression in IL-4Rα−/− mice, indicating biallelic expression of the gene for IL-4Rα (Il4ra). Concomitant with intermediate IL-4Rα expression, F1 mice showed intermediate susceptibility associated with altered Th2/Th17 cytokine production, decreased immunoglobulin E levels, and reduced allergic inflammation. This indicates a gene-dosage effect of IL-4Rα expression on susceptibility to bronchopulmonary mycosis. These data provide the basis for novel therapies antagonizing IL-4Rα in Th2-related pulmonary infection and possibly also in asthma." @default.
- W2139604805 created "2016-06-24" @default.
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- W2139604805 date "2008-12-01" @default.
- W2139604805 modified "2023-09-23" @default.
- W2139604805 title "A Gene‐Dosage Effect for Interleukin‐4 Receptor α‐Chain Expression Has an Impact on Th2‐Mediated Allergic Inflammation during Bronchopulmonary Mycosis" @default.
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- W2139604805 doi "https://doi.org/10.1086/593068" @default.
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