FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139609510> ?p ?o ?g. }

• W2139609510 endingPage "112" @default.
• W2139609510 startingPage "101" @default.
• W2139609510 abstract "Previous work has shown that proteins can be nondestructively delivered into the cytoplasm of folate receptor-bearing cells if the proteins are conjugated to folic acid prior to addition to cells. In view of other reports suggesting the membrane receptor for folic acid is vastly overexpressed on tumor cells, we decided to explore whether malignant cells might be selectively targeted in a co-culture with nontransformed cells using ligated folate as the targeting agent. Exploiting the cytotoxicity of the ribosome-inactivating toxin, momordin, to assay successful intracellular protein delivery, we demonstrate that HeLa and KB cells (two malignant human cell lines) can be selectively and quantitatively killed in co-cultures with WI38 and Hs67 cells (two normal human cell types). Not only are the normal cells not damaged by treatment of the co-cultures with momordin-folate, but their rates of proliferation actually accelerate, presumably due to increased availability of nutrients otherwise consumed by the transformed cells. Analysis of folate receptor number before and after momordin-folate treatment indicates that receptor density may be a good predictor of toxin-folate sensitivity. Taken together, the data suggest that conjugates of folic acid with cytotoxic proteins warrant further examination as possible tumor-specific chemotherapeutic agents." @default.
• W2139609510 created "2016-06-24" @default.
• W2139609510 creator A5012446734 @default.
• W2139609510 creator A5085542989 @default.
• W2139609510 date "1994-01-01" @default.
• W2139609510 modified "2023-09-25" @default.
• W2139609510 title "Selective Targeting of Malignant Cells with Cytotoxin-Folate Conjugates" @default.
• W2139609510 cites W1515543767 @default.
• W2139609510 cites W1578933663 @default.
• W2139609510 cites W1585310162 @default.
• W2139609510 cites W1592913469 @default.
• W2139609510 cites W1595469935 @default.
• W2139609510 cites W1616375115 @default.
• W2139609510 cites W1853165005 @default.
• W2139609510 cites W1998290168 @default.
• W2139609510 cites W2010132908 @default.
• W2139609510 cites W2025476834 @default.
• W2139609510 cites W2051052717 @default.
• W2139609510 cites W2053794928 @default.
• W2139609510 cites W2063431146 @default.
• W2139609510 cites W2068942638 @default.
• W2139609510 cites W2081189233 @default.
• W2139609510 cites W2084357980 @default.
• W2139609510 cites W2094435329 @default.
• W2139609510 cites W2133786616 @default.
• W2139609510 cites W2176671673 @default.
• W2139609510 doi "https://doi.org/10.3109/10611869409015898" @default.
• W2139609510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8069588" @default.
• W2139609510 hasPublicationYear "1994" @default.
• W2139609510 type Work @default.
• W2139609510 sameAs 2139609510 @default.
• W2139609510 citedByCount "98" @default.
• W2139609510 countsByYear W21396095102012 @default.
• W2139609510 countsByYear W21396095102013 @default.
• W2139609510 countsByYear W21396095102015 @default.
• W2139609510 countsByYear W21396095102016 @default.
• W2139609510 countsByYear W21396095102017 @default.
• W2139609510 countsByYear W21396095102019 @default.
• W2139609510 countsByYear W21396095102020 @default.
• W2139609510 countsByYear W21396095102021 @default.
• W2139609510 crossrefType "journal-article" @default.
• W2139609510 hasAuthorship W2139609510A5012446734 @default.
• W2139609510 hasAuthorship W2139609510A5085542989 @default.
• W2139609510 hasConcept C109316439 @default.
• W2139609510 hasConcept C115085202 @default.
• W2139609510 hasConcept C121608353 @default.
• W2139609510 hasConcept C1491633281 @default.
• W2139609510 hasConcept C154317977 @default.
• W2139609510 hasConcept C170493617 @default.
• W2139609510 hasConcept C190062978 @default.
• W2139609510 hasConcept C202751555 @default.
• W2139609510 hasConcept C2777366897 @default.
• W2139609510 hasConcept C2777367657 @default.
• W2139609510 hasConcept C2780306303 @default.
• W2139609510 hasConcept C2781260279 @default.
• W2139609510 hasConcept C54355233 @default.
• W2139609510 hasConcept C55493867 @default.
• W2139609510 hasConcept C79879829 @default.
• W2139609510 hasConcept C81885089 @default.
• W2139609510 hasConcept C86803240 @default.
• W2139609510 hasConcept C95444343 @default.
• W2139609510 hasConcept C96232424 @default.
• W2139609510 hasConceptScore W2139609510C109316439 @default.
• W2139609510 hasConceptScore W2139609510C115085202 @default.
• W2139609510 hasConceptScore W2139609510C121608353 @default.
• W2139609510 hasConceptScore W2139609510C1491633281 @default.
• W2139609510 hasConceptScore W2139609510C154317977 @default.
• W2139609510 hasConceptScore W2139609510C170493617 @default.
• W2139609510 hasConceptScore W2139609510C190062978 @default.
• W2139609510 hasConceptScore W2139609510C202751555 @default.
• W2139609510 hasConceptScore W2139609510C2777366897 @default.
• W2139609510 hasConceptScore W2139609510C2777367657 @default.
• W2139609510 hasConceptScore W2139609510C2780306303 @default.
• W2139609510 hasConceptScore W2139609510C2781260279 @default.
• W2139609510 hasConceptScore W2139609510C54355233 @default.
• W2139609510 hasConceptScore W2139609510C55493867 @default.
• W2139609510 hasConceptScore W2139609510C79879829 @default.
• W2139609510 hasConceptScore W2139609510C81885089 @default.
• W2139609510 hasConceptScore W2139609510C86803240 @default.
• W2139609510 hasConceptScore W2139609510C95444343 @default.
• W2139609510 hasConceptScore W2139609510C96232424 @default.
• W2139609510 hasIssue "2" @default.
• W2139609510 hasLocation W21396095101 @default.
• W2139609510 hasLocation W21396095102 @default.
• W2139609510 hasOpenAccess W2139609510 @default.
• W2139609510 hasPrimaryLocation W21396095101 @default.
• W2139609510 hasRelatedWork W1557687412 @default.
• W2139609510 hasRelatedWork W1601301841 @default.
• W2139609510 hasRelatedWork W1983661946 @default.
• W2139609510 hasRelatedWork W2093313172 @default.
• W2139609510 hasRelatedWork W2144548733 @default.
• W2139609510 hasRelatedWork W2277654786 @default.
• W2139609510 hasRelatedWork W2286331521 @default.
• W2139609510 hasRelatedWork W2350476853 @default.
• W2139609510 hasRelatedWork W2352626293 @default.
• W2139609510 hasRelatedWork W2951627624 @default.
• W2139609510 hasVolume "2" @default.
• W2139609510 isParatext "false" @default.

• next