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• W2139620087 abstract "Uncoupling proteins belong to the superfamily of mitochondrial anion carriers. They are apparently present throughout the Eukarya domain in which only some members have an established physiological function, i.e. UCP1 from brown adipose tissue is involved in non-shivering thermogenesis. However, the proteins responsible for the phenotype observed in unicellular organisms have not been characterized. In this report we analyzed functional evidence concerning unicellular UCPs and found that true UCPs are restricted to some taxonomical groups while proteins conferring a UCP1-like phenotype to fungi and most protists are the result of a promiscuous activity exerted by other mitochondrial anion carriers. We describe a possible evolutionary route followed by these proteins by which they acquire this promiscuous mechanism." @default.
• W2139620087 created "2016-06-24" @default.
• W2139620087 creator A5023968539 @default.
• W2139620087 date "2012-03-13" @default.
• W2139620087 modified "2023-09-27" @default.
• W2139620087 title "Uncoupling proteins (UCP) in unicellular eukaryotes: True UCPs or UCP1-like acting proteins?" @default.
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• W2139620087 doi "https://doi.org/10.1016/j.febslet.2012.03.009" @default.
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