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• W2139642783 abstract "Background. Nontyphoidal Salmonella is a leading cause of foodborne illness. Few studies have explored the health consequences of antimicrobial-resistant Salmonella. Methods. The National Antimicrobial Resistance Monitoring System (NARMS) performs susceptibility testing on nontyphoidal Salmonella isolates. The Foodborne Diseases Active Surveillance Network (FoodNet) ascertains outcomes for patients with culture-confirmed Salmonella infection, in 9 states, each of which participates inNARMS. We analyzed the frequency of bloodstream infection and hospitalization among patients with resistant infections. Isolates defined as resistant to a clinically important agent were resistant to 1 or more of the following agents: ampicillin, ceftriaxone, ciprofloxacin, gentamicin, and/or trimethoprim-sulfamethoxazole. Results. During 1996–2001, NARMS received 7370 serotyped, nontyphoidal Salmonella isolates from blood or stool. Bloodstream infection occurred more frequently among patients infected with an isolate resistant to ⩾1 clinically important agent (adjusted odds ratio [OR], 1.6; 95% confidence interval [CI], 1.2–2.1), compared with patients with pansusceptible infection. During 1996–2001, FoodNet staff ascertained outcomes for 1415 patients who had isolates tested in NARMS. Hospitalization with bloodstream infection occurred more frequently among patients infected with an isolate resistant to ⩾1 clinically important agent (adjusted OR, 3.1; 95% CI, 1.4–6.6), compared with patients with pansusceptible infection. Conclusions. Patients with antimicrobial-resistant nontyphoidal Salmonella infection were more likely to have bloodstream infection and to be hospitalized than were patients with pansusceptible infection. Mitigation of antimicrobial resistance in Salmonella will likely benefit human health." @default.
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• W2139642783 date "2005-02-15" @default.
• W2139642783 modified "2023-10-17" @default.
• W2139642783 title "Antimicrobial‐Resistant Nontyphoidal<i>Salmonella</i>Is Associated with Excess Bloodstream Infections and Hospitalizations" @default.
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• W2139642783 doi "https://doi.org/10.1086/427263" @default.
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