Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139654564> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2139654564 endingPage "743" @default.
- W2139654564 startingPage "737" @default.
- W2139654564 abstract "Object. Excessive activity of excitatory amino acids released after head trauma has been demonstrated to contribute to progressive injury in animal models and human studies. Several pharmacological agents that act as antagonists to the glutamate receptor have shown promise in limiting this progression. The efficacy of the N -methyl- d -aspartate receptor antagonist Selfotel (CGS 19755) was evaluated in two parallel studies of severely head injured patients, defined as patients with postresuscitation Glasgow Coma Scale scores of 4 to 8. Methods. A total of 693 patients were prospectively enrolled in two multicenter double-blind studies. Comparison between the treatment groups showed no significant difference with regard to demographic data, previous incidence of hypotension, and severity of injury. As the study progressed, the Safety and Monitoring Committee became concerned about possible increased deaths and serious brain-related adverse events in the treatment arm of the two head injury trials, as well as deaths in the two stroke trials being monitored concurrently. The Selfotel trials were stopped prematurely because of this concern and because an interim efficacy analysis indicated that the likelihood of demonstrating success with the agent if the studies had been completed was almost nil. Conclusions. Subsequently, more complete data analysis revealed no statistically significant difference in mortality rates in all cases between the two treatment groups in the head injury trials. In this report the authors examine the studies in detail and discuss the potential application of the data to future trial designs." @default.
- W2139654564 created "2016-06-24" @default.
- W2139654564 creator A5001985393 @default.
- W2139654564 creator A5031263597 @default.
- W2139654564 creator A5032307197 @default.
- W2139654564 creator A5052565719 @default.
- W2139654564 creator A5063003736 @default.
- W2139654564 creator A5088892217 @default.
- W2139654564 date "1999-11-01" @default.
- W2139654564 modified "2023-10-03" @default.
- W2139654564 title "Failure of the competitive N-methyl-d-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: results of two Phase III clinical trials" @default.
- W2139654564 cites W1948023428 @default.
- W2139654564 cites W1957958801 @default.
- W2139654564 cites W1981234599 @default.
- W2139654564 cites W1996929461 @default.
- W2139654564 cites W2017185655 @default.
- W2139654564 cites W2026022416 @default.
- W2139654564 cites W2027463052 @default.
- W2139654564 cites W2034521838 @default.
- W2139654564 cites W2046938783 @default.
- W2139654564 cites W2053068374 @default.
- W2139654564 cites W2059024314 @default.
- W2139654564 cites W2084962044 @default.
- W2139654564 cites W2085360535 @default.
- W2139654564 cites W2094749887 @default.
- W2139654564 cites W2143773297 @default.
- W2139654564 cites W2145903696 @default.
- W2139654564 cites W2164254780 @default.
- W2139654564 doi "https://doi.org/10.3171/jns.1999.91.5.0737" @default.
- W2139654564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10541229" @default.
- W2139654564 hasPublicationYear "1999" @default.
- W2139654564 type Work @default.
- W2139654564 sameAs 2139654564 @default.
- W2139654564 citedByCount "252" @default.
- W2139654564 countsByYear W21396545642012 @default.
- W2139654564 countsByYear W21396545642013 @default.
- W2139654564 countsByYear W21396545642014 @default.
- W2139654564 countsByYear W21396545642015 @default.
- W2139654564 countsByYear W21396545642016 @default.
- W2139654564 countsByYear W21396545642017 @default.
- W2139654564 countsByYear W21396545642018 @default.
- W2139654564 countsByYear W21396545642019 @default.
- W2139654564 countsByYear W21396545642020 @default.
- W2139654564 countsByYear W21396545642021 @default.
- W2139654564 countsByYear W21396545642022 @default.
- W2139654564 countsByYear W21396545642023 @default.
- W2139654564 crossrefType "journal-article" @default.
- W2139654564 hasAuthorship W2139654564A5001985393 @default.
- W2139654564 hasAuthorship W2139654564A5031263597 @default.
- W2139654564 hasAuthorship W2139654564A5032307197 @default.
- W2139654564 hasAuthorship W2139654564A5052565719 @default.
- W2139654564 hasAuthorship W2139654564A5063003736 @default.
- W2139654564 hasAuthorship W2139654564A5088892217 @default.
- W2139654564 hasBestOaLocation W21396545641 @default.
- W2139654564 hasConcept C126322002 @default.
- W2139654564 hasConcept C141071460 @default.
- W2139654564 hasConcept C168563851 @default.
- W2139654564 hasConcept C170493617 @default.
- W2139654564 hasConcept C17624336 @default.
- W2139654564 hasConcept C2776885963 @default.
- W2139654564 hasConcept C2777975874 @default.
- W2139654564 hasConcept C42219234 @default.
- W2139654564 hasConcept C535046627 @default.
- W2139654564 hasConcept C61943457 @default.
- W2139654564 hasConcept C71924100 @default.
- W2139654564 hasConceptScore W2139654564C126322002 @default.
- W2139654564 hasConceptScore W2139654564C141071460 @default.
- W2139654564 hasConceptScore W2139654564C168563851 @default.
- W2139654564 hasConceptScore W2139654564C170493617 @default.
- W2139654564 hasConceptScore W2139654564C17624336 @default.
- W2139654564 hasConceptScore W2139654564C2776885963 @default.
- W2139654564 hasConceptScore W2139654564C2777975874 @default.
- W2139654564 hasConceptScore W2139654564C42219234 @default.
- W2139654564 hasConceptScore W2139654564C535046627 @default.
- W2139654564 hasConceptScore W2139654564C61943457 @default.
- W2139654564 hasConceptScore W2139654564C71924100 @default.
- W2139654564 hasIssue "5" @default.
- W2139654564 hasLocation W21396545641 @default.
- W2139654564 hasLocation W21396545642 @default.
- W2139654564 hasOpenAccess W2139654564 @default.
- W2139654564 hasPrimaryLocation W21396545641 @default.
- W2139654564 hasRelatedWork W2040045829 @default.
- W2139654564 hasRelatedWork W2051882359 @default.
- W2139654564 hasRelatedWork W2070258022 @default.
- W2139654564 hasRelatedWork W2964442183 @default.
- W2139654564 hasRelatedWork W3020236348 @default.
- W2139654564 hasRelatedWork W3159250744 @default.
- W2139654564 hasRelatedWork W4256514411 @default.
- W2139654564 hasRelatedWork W4292236216 @default.
- W2139654564 hasRelatedWork W2083697902 @default.
- W2139654564 hasRelatedWork W2595575933 @default.
- W2139654564 hasVolume "91" @default.
- W2139654564 isParatext "false" @default.
- W2139654564 isRetracted "false" @default.
- W2139654564 magId "2139654564" @default.
- W2139654564 workType "article" @default.