Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139663075> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2139663075 endingPage "626" @default.
- W2139663075 startingPage "619" @default.
- W2139663075 abstract "Antisera against a partially purified prolactin-receptor preparation derived from pregnant-rabbit mammary glands were generated in guinea pigs. On double immuno-diffusion, each antiserum produced a single precipitin line with the prolactin receptors. The anti-receptor sera also specifically inhibited the binding of 125I-labelled sheep prolactin to membrane particles as well as to highly purified prolactin receptors derived from the rabbit mammary glands. The same antisera, however, had no effect on the binding of 125I-labelled insulin to the same membranes. These antisera did not bind or destroy prolactin. Moreover, the binding of 125I-LABELLED PROLACTIN TO MEMBRANE PARTICLES DErived from different tissues from a number of species was also inhibited by the antisera, thus suggesting that the immunological determinants of the prolactin receptors are similar in various tissues derived from different species. The factors in the antisera that were responsible for inhibiting the binding of 125I-labelled prolactin to its receptors were found to be associated with the gamma-globulin fraction. In addition, 131I-labelled gamma-globulins derived from one antiserum were shown to bind to membrane particles derived from mammary glands, and an increase in binding of gamma-globulin was accompanied by a decrease in binding of prolactin. Kinetic analyses of inhibition of 125I-labelled prolactin binding by antisera by using the methods of Lineweaver & Burk [J. Am. Chem. Soc. (1934) 56, 658-666] and Dixon [Biochem. J. (1953) 55, 170-171], revealed that the mechanism is a hyperbolic competitive inhibition. The demonstration of hormone-receptor-antibody complexes further favours this mechanism. The availability of anti-receptor sera should facilitate studies on the functional role as well as other biochemical, immunological and physiological properties of the prolactin receptors." @default.
- W2139663075 created "2016-06-24" @default.
- W2139663075 creator A5048583295 @default.
- W2139663075 creator A5083229654 @default.
- W2139663075 date "1976-09-01" @default.
- W2139663075 modified "2023-09-26" @default.
- W2139663075 title "Interaction of cell-membrane prolactin receptor with its antibody" @default.
- W2139663075 cites W1510593704 @default.
- W2139663075 cites W1547220187 @default.
- W2139663075 cites W1601158716 @default.
- W2139663075 cites W1775749144 @default.
- W2139663075 cites W186392394 @default.
- W2139663075 cites W1885778179 @default.
- W2139663075 cites W1966034374 @default.
- W2139663075 cites W1970638520 @default.
- W2139663075 cites W1975236443 @default.
- W2139663075 cites W2010969834 @default.
- W2139663075 cites W2014289724 @default.
- W2139663075 cites W2033785962 @default.
- W2139663075 cites W2084988392 @default.
- W2139663075 cites W2087265319 @default.
- W2139663075 cites W2219872443 @default.
- W2139663075 cites W2317759838 @default.
- W2139663075 cites W2402579832 @default.
- W2139663075 cites W2417466475 @default.
- W2139663075 cites W4242856158 @default.
- W2139663075 doi "https://doi.org/10.1042/bj1570619" @default.
- W2139663075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1163903" @default.
- W2139663075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/62572" @default.
- W2139663075 hasPublicationYear "1976" @default.
- W2139663075 type Work @default.
- W2139663075 sameAs 2139663075 @default.
- W2139663075 citedByCount "57" @default.
- W2139663075 countsByYear W21396630752017 @default.
- W2139663075 crossrefType "journal-article" @default.
- W2139663075 hasAuthorship W2139663075A5048583295 @default.
- W2139663075 hasAuthorship W2139663075A5083229654 @default.
- W2139663075 hasBestOaLocation W21396630752 @default.
- W2139663075 hasConcept C126322002 @default.
- W2139663075 hasConcept C133229898 @default.
- W2139663075 hasConcept C134018914 @default.
- W2139663075 hasConcept C153911025 @default.
- W2139663075 hasConcept C159654299 @default.
- W2139663075 hasConcept C170493617 @default.
- W2139663075 hasConcept C185592680 @default.
- W2139663075 hasConcept C197462201 @default.
- W2139663075 hasConcept C203014093 @default.
- W2139663075 hasConcept C2779064019 @default.
- W2139663075 hasConcept C2781031661 @default.
- W2139663075 hasConcept C41625074 @default.
- W2139663075 hasConcept C55493867 @default.
- W2139663075 hasConcept C71315377 @default.
- W2139663075 hasConcept C71924100 @default.
- W2139663075 hasConcept C86803240 @default.
- W2139663075 hasConcept C91523082 @default.
- W2139663075 hasConceptScore W2139663075C126322002 @default.
- W2139663075 hasConceptScore W2139663075C133229898 @default.
- W2139663075 hasConceptScore W2139663075C134018914 @default.
- W2139663075 hasConceptScore W2139663075C153911025 @default.
- W2139663075 hasConceptScore W2139663075C159654299 @default.
- W2139663075 hasConceptScore W2139663075C170493617 @default.
- W2139663075 hasConceptScore W2139663075C185592680 @default.
- W2139663075 hasConceptScore W2139663075C197462201 @default.
- W2139663075 hasConceptScore W2139663075C203014093 @default.
- W2139663075 hasConceptScore W2139663075C2779064019 @default.
- W2139663075 hasConceptScore W2139663075C2781031661 @default.
- W2139663075 hasConceptScore W2139663075C41625074 @default.
- W2139663075 hasConceptScore W2139663075C55493867 @default.
- W2139663075 hasConceptScore W2139663075C71315377 @default.
- W2139663075 hasConceptScore W2139663075C71924100 @default.
- W2139663075 hasConceptScore W2139663075C86803240 @default.
- W2139663075 hasConceptScore W2139663075C91523082 @default.
- W2139663075 hasIssue "3" @default.
- W2139663075 hasLocation W21396630751 @default.
- W2139663075 hasLocation W21396630752 @default.
- W2139663075 hasLocation W21396630753 @default.
- W2139663075 hasOpenAccess W2139663075 @default.
- W2139663075 hasPrimaryLocation W21396630751 @default.
- W2139663075 hasRelatedWork W1963919935 @default.
- W2139663075 hasRelatedWork W2053465560 @default.
- W2139663075 hasRelatedWork W2063619316 @default.
- W2139663075 hasRelatedWork W2074425511 @default.
- W2139663075 hasRelatedWork W2114525053 @default.
- W2139663075 hasRelatedWork W2129625801 @default.
- W2139663075 hasRelatedWork W2135977273 @default.
- W2139663075 hasRelatedWork W2138055319 @default.
- W2139663075 hasRelatedWork W2139663075 @default.
- W2139663075 hasRelatedWork W2152306407 @default.
- W2139663075 hasVolume "157" @default.
- W2139663075 isParatext "false" @default.
- W2139663075 isRetracted "false" @default.
- W2139663075 magId "2139663075" @default.
- W2139663075 workType "article" @default.