FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139686516> ?p ?o ?g. }

• W2139686516 endingPage "19S" @default.
• W2139686516 startingPage "15S" @default.
• W2139686516 abstract "Cytochrome P-450 (CYP) enzymes have been shown to play important roles in chemical carcinogenesis. Reports have indicated that polymorphism in CYP1A1, CYP1A2, CYP2A6, CYP2E1, and CYP2D6 are associated with an altered risk of developing cancers of the lung, bladder, liver, and colon. CYP2E1 plays an important role in alcohol metabolism and participates in the metabolic activation of various carcinogens, such as N-nitrosodimethylamine. Recently, we found repeated sequences that consist of four alleles (A1, A2, A3, and A4) and six genotypes (A1/A2, A2/A2, A2/A3, A2/A4, A3/A4 and A4/A4) of the CYP2E1 gene. In the present study, we investigated whether these polymorphisms are associated with lung cancer and esophageal cancer.DNA was isolated from blood samples of 192 healthy control subjects, 85 patients with lung cancer, and 82 patients with esophageal cancer in Japanese males. DNA samples were amplified by polymerase chain reaction in the 5'-flanking region of the CYP2E1 gene and in exon 12 in the ALDH2 gene. The tandem repeat polymorphisms were examined using DNA fragment analysis. Missense mutations in exon 12 of the ALDH2 gene were examined using fluorescence-based single strand conformational change polymorphism analysis. Written informed consent was obtained from all the subjects.In the CYP2E1 gene 5'-flanking region polymorphism, patients with esophageal cancer showed significantly higher frequency of the A4/A4 genotype compared with the control subjects (p = 0.02), but no difference was found in patients with lung cancer. The frequencies of the mutant ALDH2*2 allele were significantly higher in patients with esophageal cancer (27.7%) than in healthy control subjects (7.3%; p< 0.0001; habitual alcohol drinkers).The distribution of genotypes and allele frequencies of the tandem repeats of the 5'-flanking region of the CYP2E1 gene was significantly different in patients with esophageal cancer." @default.
• W2139686516 created "2016-06-24" @default.
• W2139686516 creator A5043458895 @default.
• W2139686516 creator A5045683929 @default.
• W2139686516 creator A5048431809 @default.
• W2139686516 creator A5051142608 @default.
• W2139686516 creator A5057314745 @default.
• W2139686516 creator A5057540866 @default.
• W2139686516 creator A5061343194 @default.
• W2139686516 creator A5063357446 @default.
• W2139686516 creator A5067371349 @default.
• W2139686516 creator A5068859962 @default.
• W2139686516 date "2002-08-01" @default.
• W2139686516 modified "2023-09-23" @default.
• W2139686516 title "Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer." @default.
• W2139686516 cites W1489200879 @default.
• W2139686516 cites W1496968467 @default.
• W2139686516 cites W1505123413 @default.
• W2139686516 cites W1527149910 @default.
• W2139686516 cites W1562445183 @default.
• W2139686516 cites W1914476337 @default.
• W2139686516 cites W1963853650 @default.
• W2139686516 cites W1964387742 @default.
• W2139686516 cites W1969395863 @default.
• W2139686516 cites W1969438931 @default.
• W2139686516 cites W1981865203 @default.
• W2139686516 cites W1983418892 @default.
• W2139686516 cites W1986930361 @default.
• W2139686516 cites W1990541549 @default.
• W2139686516 cites W1996915976 @default.
• W2139686516 cites W2024537358 @default.
• W2139686516 cites W2038909539 @default.
• W2139686516 cites W2084735442 @default.
• W2139686516 cites W2105639448 @default.
• W2139686516 cites W2106095564 @default.
• W2139686516 cites W2108124990 @default.
• W2139686516 cites W2152729754 @default.
• W2139686516 cites W2161863099 @default.
• W2139686516 cites W2186147499 @default.
• W2139686516 cites W2291185787 @default.
• W2139686516 cites W2319395651 @default.
• W2139686516 cites W2415512160 @default.
• W2139686516 doi "https://doi.org/10.1097/01.alc.0000026828.13868.b5" @default.
• W2139686516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12198369" @default.
• W2139686516 hasPublicationYear "2002" @default.
• W2139686516 type Work @default.
• W2139686516 sameAs 2139686516 @default.
• W2139686516 citedByCount "17" @default.
• W2139686516 countsByYear W21396865162013 @default.
• W2139686516 countsByYear W21396865162017 @default.
• W2139686516 crossrefType "journal-article" @default.
• W2139686516 hasAuthorship W2139686516A5043458895 @default.
• W2139686516 hasAuthorship W2139686516A5045683929 @default.
• W2139686516 hasAuthorship W2139686516A5048431809 @default.
• W2139686516 hasAuthorship W2139686516A5051142608 @default.
• W2139686516 hasAuthorship W2139686516A5057314745 @default.
• W2139686516 hasAuthorship W2139686516A5057540866 @default.
• W2139686516 hasAuthorship W2139686516A5061343194 @default.
• W2139686516 hasAuthorship W2139686516A5063357446 @default.
• W2139686516 hasAuthorship W2139686516A5067371349 @default.
• W2139686516 hasAuthorship W2139686516A5068859962 @default.
• W2139686516 hasConcept C104317684 @default.
• W2139686516 hasConcept C121608353 @default.
• W2139686516 hasConcept C126322002 @default.
• W2139686516 hasConcept C135763542 @default.
• W2139686516 hasConcept C141231307 @default.
• W2139686516 hasConcept C153911025 @default.
• W2139686516 hasConcept C27149982 @default.
• W2139686516 hasConcept C2776256026 @default.
• W2139686516 hasConcept C2779742542 @default.
• W2139686516 hasConcept C3175096 @default.
• W2139686516 hasConcept C502942594 @default.
• W2139686516 hasConcept C54355233 @default.
• W2139686516 hasConcept C71924100 @default.
• W2139686516 hasConcept C76252995 @default.
• W2139686516 hasConcept C86803240 @default.
• W2139686516 hasConceptScore W2139686516C104317684 @default.
• W2139686516 hasConceptScore W2139686516C121608353 @default.
• W2139686516 hasConceptScore W2139686516C126322002 @default.
• W2139686516 hasConceptScore W2139686516C135763542 @default.
• W2139686516 hasConceptScore W2139686516C141231307 @default.
• W2139686516 hasConceptScore W2139686516C153911025 @default.
• W2139686516 hasConceptScore W2139686516C27149982 @default.
• W2139686516 hasConceptScore W2139686516C2776256026 @default.
• W2139686516 hasConceptScore W2139686516C2779742542 @default.
• W2139686516 hasConceptScore W2139686516C3175096 @default.
• W2139686516 hasConceptScore W2139686516C502942594 @default.
• W2139686516 hasConceptScore W2139686516C54355233 @default.
• W2139686516 hasConceptScore W2139686516C71924100 @default.
• W2139686516 hasConceptScore W2139686516C76252995 @default.
• W2139686516 hasConceptScore W2139686516C86803240 @default.
• W2139686516 hasIssue "8 Suppl" @default.
• W2139686516 hasLocation W21396865161 @default.
• W2139686516 hasOpenAccess W2139686516 @default.
• W2139686516 hasPrimaryLocation W21396865161 @default.
• W2139686516 hasRelatedWork W1803914454 @default.
• W2139686516 hasRelatedWork W2006948908 @default.
• W2139686516 hasRelatedWork W2124158448 @default.

• next