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- W2139700928 abstract "Objective. To describe the clinical features, management and outcome of 34 children with chronic recurrent multifocal osteomyelitis (CRMO) diagnosed at a single centre over 9 years. Methods. All children identified with CRMO for the period 2005–13 were identified from a prospectively collected database, with additional data from hospital records. Results. Thirty-four patients, 21 female and 13 male, were identified. The average age at symptom onset was 9.8 years (range 3.8–17.9) and at diagnosis was 10.9 years (range 5.2–18.2), with an average delay in diagnosis of 12 months. Follow-up was 0.3–7.9 years (average 2.1), with 104 individual bony lesions identified, with a median of 3 (range 1–9) per patient. Six patients had unifocal disease. The sites involved included the tibia (n = 19), femur (n = 14), clavicle (n = 12), vertebrae (n = 10) and fibula (n = 8). Approximately half of patients had an inflammatory arthritis at diagnosis, and two-thirds in total eventually developed an arthritis. Pustulosis occurred in eight patients (24%), severe acne in four (12%) and psoriasis in three (9%). NSAIDs were used in 91%, CSs in 82% and MTX in 38%. Two patients were treated with anti-TNF agents. Episodic disease was most common (79%), while 21% had a monophasic pattern. Clinical remission occurred in 94% of children, with prolonged remission in 17%. Seven patients did not require medications for >12 months. Conclusion. CRMO is more common than previously recognized, but diagnosis may be delayed. Episodic multifocal disease was most common, but some had unifocal and/or monophasic disease. Most patients responded to NSAIDs and/or intermittent CSs, but many required DMARDs." @default.
- W2139700928 created "2016-06-24" @default.
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- W2139700928 date "2015-05-03" @default.
- W2139700928 modified "2023-10-16" @default.
- W2139700928 title "Chronic recurrent multifocal osteomyelitis in children: nine years’ experience at a statewide tertiary paediatric rheumatology referral centre" @default.
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- W2139700928 doi "https://doi.org/10.1093/rheumatology/kev013" @default.
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