FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139725953> ?p ?o ?g. }

• W2139725953 endingPage "1292" @default.
• W2139725953 startingPage "1287" @default.
• W2139725953 abstract "The mechanisms underlying drug resistance in colorectal cancer (CRC) treatment remain to be fully elucidated. Therefore, the present study aimed to investigate the underlying mechanism resistance to a widely used anticancer drug, 5‑Fluorouracil (5‑FU). Nuclear factor‑erythroid 2‑related factor 2 (Nrf2) is an important transcription factor involved in cellular protection. In the present study, it was hypothesized that the epigenetic modification of Nrf2 may be a potential target for 5‑FU resistance in CRC treatment. Protein and messenger RNA levels of Nrf2, heme oxygenase‑1 (HO‑1), DNA methylases and DNA methyltransferases were determined and DNA methylation analysis for the Nrf2 promoter was performed in a human CRC control (SNU‑C5) and resistant (SNU‑C5R) cell line. The results demonstrated that Nrf2 expression levels, nuclear translocation and promoter binding were significantly increased in SNU‑C5R cells compared with SNU‑C5 cells. Elevated levels of activated Nrf2 in SNU‑C5R cells resulted in the increased protein expression and activity of HO‑1. In addition, increased production of reactive oxygen species (ROS) and upregulation of ten‑eleven translocation (TET)1 were observed in SNU‑C5R cells compared with SNU‑C5 cells. Furthermore, methylation analysis revealed Nrf2 promoter cytosine‑phosphate‑guanine island hypomethylation in 5‑FU‑treated cells. In conclusion, the results indicated that 5‑FU‑induced ROS production resulted in the upregulation of TET1 expression and function. In addition, these results indicated that TET‑dependent demethylation of the Nrf2 promoter upregulated Nrf2 and HO‑1 expression, which induced cellular protection mechanisms, ultimately leading to drug resistance." @default.
• W2139725953 created "2016-06-24" @default.
• W2139725953 creator A5014920830 @default.
• W2139725953 creator A5017251333 @default.
• W2139725953 creator A5021935765 @default.
• W2139725953 creator A5028514664 @default.
• W2139725953 creator A5085137414 @default.
• W2139725953 date "2015-07-08" @default.
• W2139725953 modified "2023-09-27" @default.
• W2139725953 title "Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells" @default.
• W2139725953 cites W1965784823 @default.
• W2139725953 cites W1967108243 @default.
• W2139725953 cites W1969955520 @default.
• W2139725953 cites W1971463658 @default.
• W2139725953 cites W1972793256 @default.
• W2139725953 cites W1973562117 @default.
• W2139725953 cites W1981463058 @default.
• W2139725953 cites W1983565617 @default.
• W2139725953 cites W1991486518 @default.
• W2139725953 cites W1992867510 @default.
• W2139725953 cites W1994670373 @default.
• W2139725953 cites W1997453048 @default.
• W2139725953 cites W2004826992 @default.
• W2139725953 cites W2022408375 @default.
• W2139725953 cites W2023544069 @default.
• W2139725953 cites W2036986058 @default.
• W2139725953 cites W2042530916 @default.
• W2139725953 cites W2055117588 @default.
• W2139725953 cites W2056473117 @default.
• W2139725953 cites W2067182723 @default.
• W2139725953 cites W2073463952 @default.
• W2139725953 cites W2073902410 @default.
• W2139725953 cites W2073910776 @default.
• W2139725953 cites W2092677877 @default.
• W2139725953 cites W2093683863 @default.
• W2139725953 cites W2097634036 @default.
• W2139725953 cites W2112344373 @default.
• W2139725953 cites W2124418078 @default.
• W2139725953 cites W2125762200 @default.
• W2139725953 cites W2127497086 @default.
• W2139725953 cites W2130121207 @default.
• W2139725953 cites W2130392703 @default.
• W2139725953 cites W2134703818 @default.
• W2139725953 cites W2142595050 @default.
• W2139725953 cites W2143978768 @default.
• W2139725953 cites W2145534945 @default.
• W2139725953 cites W2161446823 @default.
• W2139725953 cites W2165643859 @default.
• W2139725953 cites W2168395641 @default.
• W2139725953 doi "https://doi.org/10.3892/ol.2015.3468" @default.
• W2139725953 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4533726" @default.
• W2139725953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26622665" @default.
• W2139725953 hasPublicationYear "2015" @default.
• W2139725953 type Work @default.
• W2139725953 sameAs 2139725953 @default.
• W2139725953 citedByCount "31" @default.
• W2139725953 countsByYear W21397259532016 @default.
• W2139725953 countsByYear W21397259532017 @default.
• W2139725953 countsByYear W21397259532018 @default.
• W2139725953 countsByYear W21397259532019 @default.
• W2139725953 countsByYear W21397259532020 @default.
• W2139725953 countsByYear W21397259532021 @default.
• W2139725953 countsByYear W21397259532022 @default.
• W2139725953 countsByYear W21397259532023 @default.
• W2139725953 crossrefType "journal-article" @default.
• W2139725953 hasAuthorship W2139725953A5014920830 @default.
• W2139725953 hasAuthorship W2139725953A5017251333 @default.
• W2139725953 hasAuthorship W2139725953A5021935765 @default.
• W2139725953 hasAuthorship W2139725953A5028514664 @default.
• W2139725953 hasAuthorship W2139725953A5085137414 @default.
• W2139725953 hasBestOaLocation W21397259531 @default.
• W2139725953 hasConcept C104317684 @default.
• W2139725953 hasConcept C127561419 @default.
• W2139725953 hasConcept C1491633281 @default.
• W2139725953 hasConcept C150194340 @default.
• W2139725953 hasConcept C153911025 @default.
• W2139725953 hasConcept C16824249 @default.
• W2139725953 hasConcept C185592680 @default.
• W2139725953 hasConcept C190727270 @default.
• W2139725953 hasConcept C202199734 @default.
• W2139725953 hasConcept C2781018059 @default.
• W2139725953 hasConcept C29537977 @default.
• W2139725953 hasConcept C33288867 @default.
• W2139725953 hasConcept C41091548 @default.
• W2139725953 hasConcept C502942594 @default.
• W2139725953 hasConcept C55493867 @default.
• W2139725953 hasConcept C86339819 @default.
• W2139725953 hasConcept C86803240 @default.
• W2139725953 hasConcept C91965660 @default.
• W2139725953 hasConceptScore W2139725953C104317684 @default.
• W2139725953 hasConceptScore W2139725953C127561419 @default.
• W2139725953 hasConceptScore W2139725953C1491633281 @default.
• W2139725953 hasConceptScore W2139725953C150194340 @default.
• W2139725953 hasConceptScore W2139725953C153911025 @default.
• W2139725953 hasConceptScore W2139725953C16824249 @default.
• W2139725953 hasConceptScore W2139725953C185592680 @default.
• W2139725953 hasConceptScore W2139725953C190727270 @default.
• W2139725953 hasConceptScore W2139725953C202199734 @default.

• next