FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139731421> ?p ?o ?g. }

• W2139731421 endingPage "e62882" @default.
• W2139731421 startingPage "e62882" @default.
• W2139731421 abstract "The DREAM complex plays an important role in regulation of gene expression during the cell cycle. We have previously shown that the DREAM subunit LIN9 is required for early embryonic development and for the maintenance of the inner cell mass in vitro. In this study we examined the effect of knocking down LIN9 on ESCs. We demonstrate that depletion of LIN9 alters the cell cycle distribution of ESCs and results in an accumulation of cells in G2 and M and in an increase of polyploid cells. Genome-wide expression studies showed that the depletion of LIN9 results in downregulation of mitotic genes and in upregulation of differentiation-specific genes. ChIP-on chip experiments showed that mitotic genes are direct targets of LIN9 while lineage specific markers are regulated indirectly. Importantly, depletion of LIN9 does not alter the expression of pluripotency markers SOX2, OCT4 and Nanog and LIN9 depleted ESCs retain alkaline phosphatase activity. We conclude that LIN9 is essential for proliferation and genome stability of ESCs by activating genes with important functions in mitosis and cytokinesis." @default.
• W2139731421 created "2016-06-24" @default.
• W2139731421 creator A5013845611 @default.
• W2139731421 creator A5032004705 @default.
• W2139731421 creator A5033917552 @default.
• W2139731421 creator A5047226245 @default.
• W2139731421 creator A5065509792 @default.
• W2139731421 creator A5074854214 @default.
• W2139731421 date "2013-05-07" @default.
• W2139731421 modified "2023-10-02" @default.
• W2139731421 title "LIN9, a Subunit of the DREAM Complex, Regulates Mitotic Gene Expression and Proliferation of Embryonic Stem Cells" @default.
• W2139731421 cites W1979256988 @default.
• W2139731421 cites W1981088384 @default.
• W2139731421 cites W1981976632 @default.
• W2139731421 cites W1990220015 @default.
• W2139731421 cites W1993340233 @default.
• W2139731421 cites W2007314850 @default.
• W2139731421 cites W2012995139 @default.
• W2139731421 cites W2016783637 @default.
• W2139731421 cites W2017050785 @default.
• W2139731421 cites W2017350635 @default.
• W2139731421 cites W2021494076 @default.
• W2139731421 cites W2041888539 @default.
• W2139731421 cites W2042794853 @default.
• W2139731421 cites W2045067678 @default.
• W2139731421 cites W2045899482 @default.
• W2139731421 cites W2049261415 @default.
• W2139731421 cites W2051852464 @default.
• W2139731421 cites W2053700159 @default.
• W2139731421 cites W2055156816 @default.
• W2139731421 cites W2058414986 @default.
• W2139731421 cites W2059568263 @default.
• W2139731421 cites W2076840637 @default.
• W2139731421 cites W2077264573 @default.
• W2139731421 cites W2083325714 @default.
• W2139731421 cites W2089255240 @default.
• W2139731421 cites W2105966971 @default.
• W2139731421 cites W2107733431 @default.
• W2139731421 cites W2110893450 @default.
• W2139731421 cites W2126441143 @default.
• W2139731421 cites W2128187370 @default.
• W2139731421 cites W2135447662 @default.
• W2139731421 cites W2136107875 @default.
• W2139731421 cites W2137542804 @default.
• W2139731421 cites W2150693815 @default.
• W2139731421 cites W2153198916 @default.
• W2139731421 cites W2156397151 @default.
• W2139731421 cites W2171006421 @default.
• W2139731421 cites W2325068802 @default.
• W2139731421 doi "https://doi.org/10.1371/journal.pone.0062882" @default.
• W2139731421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3647048" @default.
• W2139731421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23667535" @default.
• W2139731421 hasPublicationYear "2013" @default.
• W2139731421 type Work @default.
• W2139731421 sameAs 2139731421 @default.
• W2139731421 citedByCount "17" @default.
• W2139731421 countsByYear W21397314212016 @default.
• W2139731421 countsByYear W21397314212017 @default.
• W2139731421 countsByYear W21397314212019 @default.
• W2139731421 countsByYear W21397314212020 @default.
• W2139731421 countsByYear W21397314212021 @default.
• W2139731421 countsByYear W21397314212022 @default.
• W2139731421 countsByYear W21397314212023 @default.
• W2139731421 crossrefType "journal-article" @default.
• W2139731421 hasAuthorship W2139731421A5013845611 @default.
• W2139731421 hasAuthorship W2139731421A5032004705 @default.
• W2139731421 hasAuthorship W2139731421A5033917552 @default.
• W2139731421 hasAuthorship W2139731421A5047226245 @default.
• W2139731421 hasAuthorship W2139731421A5065509792 @default.
• W2139731421 hasAuthorship W2139731421A5074854214 @default.
• W2139731421 hasBestOaLocation W21397314211 @default.
• W2139731421 hasConcept C104317684 @default.
• W2139731421 hasConcept C107459253 @default.
• W2139731421 hasConcept C127561419 @default.
• W2139731421 hasConcept C145103041 @default.
• W2139731421 hasConcept C148738053 @default.
• W2139731421 hasConcept C1491633281 @default.
• W2139731421 hasConcept C165864922 @default.
• W2139731421 hasConcept C207701140 @default.
• W2139731421 hasConcept C2777933648 @default.
• W2139731421 hasConcept C28328180 @default.
• W2139731421 hasConcept C29537977 @default.
• W2139731421 hasConcept C45472230 @default.
• W2139731421 hasConcept C54355233 @default.
• W2139731421 hasConcept C85813293 @default.
• W2139731421 hasConcept C86803240 @default.
• W2139731421 hasConcept C93304396 @default.
• W2139731421 hasConcept C95444343 @default.
• W2139731421 hasConceptScore W2139731421C104317684 @default.
• W2139731421 hasConceptScore W2139731421C107459253 @default.
• W2139731421 hasConceptScore W2139731421C127561419 @default.
• W2139731421 hasConceptScore W2139731421C145103041 @default.
• W2139731421 hasConceptScore W2139731421C148738053 @default.
• W2139731421 hasConceptScore W2139731421C1491633281 @default.
• W2139731421 hasConceptScore W2139731421C165864922 @default.
• W2139731421 hasConceptScore W2139731421C207701140 @default.
• W2139731421 hasConceptScore W2139731421C2777933648 @default.
• W2139731421 hasConceptScore W2139731421C28328180 @default.

• next