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• W2139735087 abstract "Germline apoptosis shares with somatic apoptosis a reliance on key components of the core apoptotic machinery, including CED-3 and CED-4. However, germline apoptosis differs from somatic apoptosis in its regulation. Whereas somatic apoptosis is developmentally programmed by cell lineage, germline apoptosis occurs as part of an oogenesis program. One category of germline apoptosis, dubbed physiological germline apoptosis, reduces the number of cells that complete oogenesis, and is independent of the BH3-only apoptosis effecter EGL-1. A second category, termed stress-induced germline apoptosis, is triggered by a genomic integrity checkpoint. Some mechanisms that are monitored by this DNA-damage checkpoint are also involved in germ cell immortality, or preservation of a continuous germ cell lineage over successive generations. In addition, exposure to certain environmental insults or pathogens induces germ cell apoptosis. Here we will review the mechanisms that control each of the pathways leading to germ cell apoptosis and discuss their functional significance. Germline apoptosis is an integral part of oogenesis in many animals, including humans. Because many of the regulators of C. elegans germline apoptosis are conserved, we suggest that this nematode provides a valuable model for understanding controls of germline apoptosis more broadly." @default.
• W2139735087 created "2016-06-24" @default.
• W2139735087 date "2008-09-05" @default.
• W2139735087 modified "2023-10-14" @default.
• W2139735087 title "WormBook" @default.
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• W2139735087 doi "https://doi.org/10.1895/wormbook.1.145.1" @default.
• W2139735087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4781258" @default.

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