FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139737586> ?p ?o ?g. }

• W2139737586 abstract "Oocyte-specific histone variants have been expected to play significant roles in early embryonic development, but the exact evidence and the biological function have remained unclear. Here, we present evidence that H2af1o, an oocyte-specific H2A variant, is required for cell synchrony before midblastula transition in early zebrafish embryos. The H2A variant is oocyte specific, peaks in mature eggs, and is supplied to early embryos. We constructed a series of deletion plasmids of the zebrafish h2af1o tagged with EGFP and determined the main key function regions including nuclear localization signal of N-terminal 25 amino acids and nucleosome binding region of 110–122 amino acid sequence in the C-terminus by microinjecting them into one-cell-stage zebrafish embryos. In comparison with ubiquitous H2A.X, the H2af1o was revealed to confer a more open structure than canonical H2A in the nucleosomes. Furthermore, we conducted the h2af1o-specific morpholino knockdown analysis in early embryos of zebrafish and revealed its biological function for maintaining cell synchrony division because the H2af1o deficiency disturbed cell synchrony in early cleavages before midblastula transition. Therefore, our current findings provided the first case to understand the biological function of maternal oocyte-specific histone variants in vertebrates." @default.
• W2139737586 created "2016-06-24" @default.
• W2139737586 creator A5021128215 @default.
• W2139737586 creator A5026495597 @default.
• W2139737586 creator A5030556972 @default.
• W2139737586 creator A5040009629 @default.
• W2139737586 creator A5043243831 @default.
• W2139737586 creator A5058479146 @default.
• W2139737586 date "2013-10-01" @default.
• W2139737586 modified "2023-09-23" @default.
• W2139737586 title "Oocyte-Specific H2A Variant H2af1o Is Required for Cell Synchrony Before Midblastula Transition in Early Zebrafish Embryos1" @default.
• W2139737586 cites W183376958 @default.
• W2139737586 cites W1961074127 @default.
• W2139737586 cites W1965762845 @default.
• W2139737586 cites W1971765644 @default.
• W2139737586 cites W1977874695 @default.
• W2139737586 cites W1979156811 @default.
• W2139737586 cites W1979667801 @default.
• W2139737586 cites W2014659499 @default.
• W2139737586 cites W2020581192 @default.
• W2139737586 cites W2022193145 @default.
• W2139737586 cites W2023058113 @default.
• W2139737586 cites W2023440457 @default.
• W2139737586 cites W2028630156 @default.
• W2139737586 cites W2033810913 @default.
• W2139737586 cites W2033856541 @default.
• W2139737586 cites W2039751052 @default.
• W2139737586 cites W2041608145 @default.
• W2139737586 cites W2044428841 @default.
• W2139737586 cites W2048682303 @default.
• W2139737586 cites W2051105738 @default.
• W2139737586 cites W2052706262 @default.
• W2139737586 cites W2053188090 @default.
• W2139737586 cites W2063295516 @default.
• W2139737586 cites W2065571115 @default.
• W2139737586 cites W2066293068 @default.
• W2139737586 cites W2070663406 @default.
• W2139737586 cites W2081371026 @default.
• W2139737586 cites W2082114538 @default.
• W2139737586 cites W2096251733 @default.
• W2139737586 cites W2097633421 @default.
• W2139737586 cites W2101248283 @default.
• W2139737586 cites W2104247353 @default.
• W2139737586 cites W2114570899 @default.
• W2139737586 cites W2123026728 @default.
• W2139737586 cites W2125302836 @default.
• W2139737586 cites W2125349610 @default.
• W2139737586 cites W2129011493 @default.
• W2139737586 cites W2132399813 @default.
• W2139737586 cites W2134256488 @default.
• W2139737586 cites W2135375502 @default.
• W2139737586 cites W2137859768 @default.
• W2139737586 cites W2142358355 @default.
• W2139737586 cites W2144792857 @default.
• W2139737586 cites W2145924925 @default.
• W2139737586 cites W2156104195 @default.
• W2139737586 cites W2167831844 @default.
• W2139737586 cites W2169782046 @default.
• W2139737586 cites W2170832102 @default.
• W2139737586 doi "https://doi.org/10.1095/biolreprod.113.108043" @default.
• W2139737586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23946537" @default.
• W2139737586 hasPublicationYear "2013" @default.
• W2139737586 type Work @default.
• W2139737586 sameAs 2139737586 @default.
• W2139737586 citedByCount "24" @default.
• W2139737586 countsByYear W21397375862014 @default.
• W2139737586 countsByYear W21397375862015 @default.
• W2139737586 countsByYear W21397375862016 @default.
• W2139737586 countsByYear W21397375862017 @default.
• W2139737586 countsByYear W21397375862018 @default.
• W2139737586 countsByYear W21397375862019 @default.
• W2139737586 countsByYear W21397375862020 @default.
• W2139737586 countsByYear W21397375862022 @default.
• W2139737586 crossrefType "journal-article" @default.
• W2139737586 hasAuthorship W2139737586A5021128215 @default.
• W2139737586 hasAuthorship W2139737586A5026495597 @default.
• W2139737586 hasAuthorship W2139737586A5030556972 @default.
• W2139737586 hasAuthorship W2139737586A5040009629 @default.
• W2139737586 hasAuthorship W2139737586A5043243831 @default.
• W2139737586 hasAuthorship W2139737586A5058479146 @default.
• W2139737586 hasBestOaLocation W21397375861 @default.
• W2139737586 hasConcept C104317684 @default.
• W2139737586 hasConcept C173396325 @default.
• W2139737586 hasConcept C196843134 @default.
• W2139737586 hasConcept C2776690073 @default.
• W2139737586 hasConcept C2776878037 @default.
• W2139737586 hasConcept C54355233 @default.
• W2139737586 hasConcept C64927066 @default.
• W2139737586 hasConcept C86803240 @default.
• W2139737586 hasConcept C95444343 @default.
• W2139737586 hasConceptScore W2139737586C104317684 @default.
• W2139737586 hasConceptScore W2139737586C173396325 @default.
• W2139737586 hasConceptScore W2139737586C196843134 @default.
• W2139737586 hasConceptScore W2139737586C2776690073 @default.
• W2139737586 hasConceptScore W2139737586C2776878037 @default.
• W2139737586 hasConceptScore W2139737586C54355233 @default.
• W2139737586 hasConceptScore W2139737586C64927066 @default.
• W2139737586 hasConceptScore W2139737586C86803240 @default.
• W2139737586 hasConceptScore W2139737586C95444343 @default.
• W2139737586 hasIssue "4" @default.

• next