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- W2139745644 abstract "ABSTRACT Members of a family of N -arylsulfonyl hydrazones have been identified as novel inhibitors of IMP-1, a metallo-β-lactamase of increasing prevalence. Structure-activity relationship studies have indicated a requirement for bulky aromatic substituents on each side of the sulfonyl hydrazone backbone for these compounds to serve as efficient inhibitors of IMP-1. Molecular modeling has provided insight into the structural basis for the anti-metallo-β-lactamase activity exhibited by this class of compounds." @default.
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- W2139745644 date "2002-08-01" @default.
- W2139745644 modified "2023-10-03" @default.
- W2139745644 title "<i>N</i>-Arylsulfonyl Hydrazones as Inhibitors of IMP-1 Metallo-β-Lactamase" @default.
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- W2139745644 doi "https://doi.org/10.1128/aac.46.8.2450-2457.2002" @default.
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