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- W2139746915 abstract "The Hippo pathway, which is conserved from Drosophila to mammals, has been recognized as a tumor suppressor signaling pathway governing cell proliferation and apoptosis, two key events involved in organ size control and tumorigenesis. Although several upstream regulators, the conserved kinase cascade and key downstream effectors including nuclear transcriptional factors have been defined, the global organization of this signaling pathway is not been fully understood. Thus, we conducted a proteomic analysis of human Hippo pathway, which revealed the involvement of an extensive protein-protein interaction network in this pathway. The mass spectrometry data were deposited to ProteomeXchange with identifier PXD000415. Our data suggest that 550 interactions within 343 unique protein components constitute the central protein-protein interaction landscape of human Hippo pathway. Our study provides a glimpse into the global organization of Hippo pathway, reveals previously unknown interactions within this pathway, and uncovers new potential components involved in the regulation of this pathway. Understanding these interactions will help us further dissect the Hippo signaling-pathway and extend our knowledge of organ size control." @default.
- W2139746915 created "2016-06-24" @default.
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- W2139746915 creator A5078572492 @default.
- W2139746915 creator A5086597104 @default.
- W2139746915 creator A5087790751 @default.
- W2139746915 date "2014-01-01" @default.
- W2139746915 modified "2023-10-16" @default.
- W2139746915 title "Defining the Protein–Protein Interaction Network of the Human Hippo Pathway" @default.
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- W2139746915 doi "https://doi.org/10.1074/mcp.m113.030049" @default.
- W2139746915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3879608" @default.
- W2139746915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24126142" @default.
- W2139746915 hasPublicationYear "2014" @default.
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