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- W213979 abstract "ABSTRACT Stimulation-induced release of noradrenaline from guinea-pig atria with 4 pulses is greater at 0.25, 0.5 and 1 Hz than at 0.125 and 2 Hz. Phentolamine increases the release with the intermediate but not the lowest and highest frequencies. These findings indicate that there is a delay of at least 1.5 s (at 2 Hz) before the autoinhibitory feedback loop comes into operation, and the autoinhibition persists for less than 8 s (the pulse interval at 0.125 Hz). In pithed rats, the autoinhibitory feedback loop is in operation when spinal sympathetic stimulation is at 2 Hz for 10 s (21 pulses) but not at 0.5 Hz for 10 s (6 pulses). When the loop is operating, phentolamine blocks pressor responses to noradrenaline to a greater extent than those to stimulation, yohimbine enhances responses to stimulation but blocks responses to noradrenaline, and prazosin blocks both responses equally, indicating unselective, selective prejunctional, and selective postjunctional actions, respectively. The selectivity is lost when the autoinhibitory feedback loop is not activated." @default.
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- W213979 date "1982-01-01" @default.
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- W213979 title "The Time Course of the Development and Persistence of the Autoinhibitory Effect in Noradrenergic Transmission" @default.
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- W213979 doi "https://doi.org/10.1016/b978-0-08-028022-6.50016-3" @default.
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