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• W2139797686 startingPage "7759" @default.
• W2139797686 abstract "Abstract Acquired T cell immunity is central for protection against infection. However, the immunological consequences of exposing memory T cells to high Ag loads during acute and persistent infection with systemic pathogens are poorly understood. We investigated this by using infection with Anaplasma marginale, a ruminant pathogen that replicates to levels of 109 bacteria per ml of blood during acute infection and maintains mean bacteremia levels of 106 per ml during long-term persistent infection. We established that immunization-induced Ag-specific peripheral blood CD4+ T cell responses were rapidly and permanently lost following infection. To determine whether these T cells were anergic, sequestered in the spleen, or physically deleted from peripheral blood, CD4+ T lymphocytes from the peripheral blood specific for the major surface protein (MSP) 1a T cell epitope were enumerated by DRB3*1101 tetramer staining and FACS analysis throughout the course of immunization and challenge. Immunization induced significant epitope-specific T lymphocyte responses that rapidly declined near peak bacteremia to background levels. Concomitantly, the mean frequency of tetramer+CD4+ cells decreased rapidly from 0.025% before challenge to a preimmunization level of 0.0003% of CD4+ T cells. Low frequencies of tetramer+CD4+ T cells in spleen, liver, and inguinal lymph nodes sampled 9–12 wk postchallenge were consistent with undetectable or unsustainable Ag-specific responses and the lack of T cell sequestration. Thus, infection of cattle with A. marginale leads to the rapid loss of Ag-specific T cells and immunologic memory, which may be a strategy for this pathogen to modulate the immune response and persist." @default.
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• W2139797686 date "2008-12-01" @default.
• W2139797686 modified "2023-10-10" @default.
• W2139797686 title "Rapid Deletion of Antigen-Specific CD4+ T Cells following Infection Represents a Strategy of Immune Evasion and Persistence for <i>Anaplasma marginale</i>" @default.
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• W2139797686 doi "https://doi.org/10.4049/jimmunol.181.11.7759" @default.
• W2139797686 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2815346" @default.
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