FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139797826> ?p ?o ?g. }

• W2139797826 abstract "Chemical space is enormously huge but not all of it is pertinent for the drug designing. Virtual screening methods act as knowledge-based filters to discover the coveted novel lead molecules possessing desired pharmacological properties. Support Vector Machines (SVM) is a reliable virtual screening tool for prioritizing molecules with the required biological activity and minimum toxicity. It has to its credit inherent advantages such as support for noisy data mainly coming from varied high-throughput biological assays, high sensitivity, specificity, prediction accuracy and reduction in false positives. SVM-based classification methods can efficiently discriminate inhibitors from non-inhibitors, actives from inactives, toxic from non-toxic and promiscuous from non-promiscuous molecules. As the principles of drug design are also applicable for agrochemicals, SVM methods are being applied for virtual screening for pesticides too. The current review discusses the basic kernels and models used for binary discrimination and also features used for developing SVM-based scoring functions, which will enhance our understanding of molecular interactions. SVM modeling has also been compared by many researchers with other statistical methods such as Artificial Neural Networks, k-nearest neighbour (kNN), decision trees, partial least squares, etc. Such studies have also been discussed in this review. Moreover, a case study involving the use of SVM method for screening molecules for cancer therapy has been carried out and the preliminary results presented here indicate that the SVM is an excellent classifier for screening the molecules." @default.
• W2139797826 created "2016-06-24" @default.
• W2139797826 creator A5063771906 @default.
• W2139797826 creator A5067826619 @default.
• W2139797826 creator A5087772789 @default.
• W2139797826 date "2012-06-20" @default.
• W2139797826 modified "2023-09-26" @default.
• W2139797826 title "APPLICATIONS OF SUPPORT VECTOR MACHINES AS A ROBUST TOOL IN HIGH THROUGHPUT VIRTUAL SCREENING" @default.
• W2139797826 cites W1768257245 @default.
• W2139797826 cites W1965617737 @default.
• W2139797826 cites W1969001441 @default.
• W2139797826 cites W1980775965 @default.
• W2139797826 cites W1988534836 @default.
• W2139797826 cites W1997177391 @default.
• W2139797826 cites W1997881692 @default.
• W2139797826 cites W1997920842 @default.
• W2139797826 cites W1998763573 @default.
• W2139797826 cites W1998848097 @default.
• W2139797826 cites W1999348999 @default.
• W2139797826 cites W2001722230 @default.
• W2139797826 cites W2003910128 @default.
• W2139797826 cites W2004879435 @default.
• W2139797826 cites W2011773299 @default.
• W2139797826 cites W2017640164 @default.
• W2139797826 cites W2019716850 @default.
• W2139797826 cites W2019931042 @default.
• W2139797826 cites W2020756525 @default.
• W2139797826 cites W2024224430 @default.
• W2139797826 cites W2026429211 @default.
• W2139797826 cites W2028265816 @default.
• W2139797826 cites W2030322724 @default.
• W2139797826 cites W2031153203 @default.
• W2139797826 cites W2039864411 @default.
• W2139797826 cites W2042022290 @default.
• W2139797826 cites W2047070075 @default.
• W2139797826 cites W2058557545 @default.
• W2139797826 cites W2058984761 @default.
• W2139797826 cites W2062275029 @default.
• W2139797826 cites W2078240823 @default.
• W2139797826 cites W2081301924 @default.
• W2139797826 cites W2086442285 @default.
• W2139797826 cites W2087155419 @default.
• W2139797826 cites W2116296021 @default.
• W2139797826 cites W2122554885 @default.
• W2139797826 cites W2123737232 @default.
• W2139797826 cites W2125335678 @default.
• W2139797826 cites W2130583772 @default.
• W2139797826 cites W2135514714 @default.
• W2139797826 cites W2135835957 @default.
• W2139797826 cites W2144070700 @default.
• W2139797826 cites W2145784250 @default.
• W2139797826 cites W2151582714 @default.
• W2139797826 cites W2152523366 @default.
• W2139797826 cites W2154091398 @default.
• W2139797826 cites W2177508090 @default.
• W2139797826 cites W2419105462 @default.
• W2139797826 cites W2949243165 @default.
• W2139797826 cites W3023786531 @default.
• W2139797826 cites W417995331 @default.
• W2139797826 doi "https://doi.org/10.34040/ijcb.1.1.2012.12" @default.
• W2139797826 hasPublicationYear "2012" @default.
• W2139797826 type Work @default.
• W2139797826 sameAs 2139797826 @default.
• W2139797826 citedByCount "1" @default.
• W2139797826 countsByYear W21397978262018 @default.
• W2139797826 crossrefType "journal-article" @default.
• W2139797826 hasAuthorship W2139797826A5063771906 @default.
• W2139797826 hasAuthorship W2139797826A5067826619 @default.
• W2139797826 hasAuthorship W2139797826A5087772789 @default.
• W2139797826 hasBestOaLocation W21397978261 @default.
• W2139797826 hasConcept C103697762 @default.
• W2139797826 hasConcept C119857082 @default.
• W2139797826 hasConcept C12267149 @default.
• W2139797826 hasConcept C124101348 @default.
• W2139797826 hasConcept C153180895 @default.
• W2139797826 hasConcept C154945302 @default.
• W2139797826 hasConcept C164126121 @default.
• W2139797826 hasConcept C164923092 @default.
• W2139797826 hasConcept C41008148 @default.
• W2139797826 hasConcept C60644358 @default.
• W2139797826 hasConcept C64869954 @default.
• W2139797826 hasConcept C66905080 @default.
• W2139797826 hasConcept C74187038 @default.
• W2139797826 hasConcept C86803240 @default.
• W2139797826 hasConceptScore W2139797826C103697762 @default.
• W2139797826 hasConceptScore W2139797826C119857082 @default.
• W2139797826 hasConceptScore W2139797826C12267149 @default.
• W2139797826 hasConceptScore W2139797826C124101348 @default.
• W2139797826 hasConceptScore W2139797826C153180895 @default.
• W2139797826 hasConceptScore W2139797826C154945302 @default.
• W2139797826 hasConceptScore W2139797826C164126121 @default.
• W2139797826 hasConceptScore W2139797826C164923092 @default.
• W2139797826 hasConceptScore W2139797826C41008148 @default.
• W2139797826 hasConceptScore W2139797826C60644358 @default.
• W2139797826 hasConceptScore W2139797826C64869954 @default.
• W2139797826 hasConceptScore W2139797826C66905080 @default.
• W2139797826 hasConceptScore W2139797826C74187038 @default.
• W2139797826 hasConceptScore W2139797826C86803240 @default.
• W2139797826 hasLocation W21397978261 @default.
• W2139797826 hasOpenAccess W2139797826 @default.

• next