FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139798412> ?p ?o ?g. }

• W2139798412 endingPage "520" @default.
• W2139798412 startingPage "513" @default.
• W2139798412 abstract "The authors devised a method for detecting the bioluminescent Ca2+ sensor GFP-Aequorin in freely behaving zebrafish larvae. To demonstrate the efficacy of the technique, they targeted the sensor to a genetically specified population of hypothalamic neurons. The resulting neuroluminescence reveals patterns of neuronal activity that are associated with distinct swimming behaviors. Existing techniques for monitoring neural activity in awake, freely behaving vertebrates are invasive and difficult to target to genetically identified neurons. We used bioluminescence to non-invasively monitor the activity of genetically specified neurons in freely behaving zebrafish. Transgenic fish with the Ca2+-sensitive photoprotein green fluorescent protein (GFP)-Aequorin in most neurons generated large and fast bioluminescent signals that were related to neural activity, neuroluminescence, which could be recorded continuously for many days. To test the limits of this technique, we specifically targeted GFP-Aequorin to the hypocretin-positive neurons of the hypothalamus. We found that neuroluminescence generated by this group of ∼20 neurons was associated with periods of increased locomotor activity and identified two classes of neural activity corresponding to distinct swim latencies. Our neuroluminescence assay can report, with high temporal resolution and sensitivity, the activity of small subsets of neurons during unrestrained behavior." @default.
• W2139798412 created "2016-06-24" @default.
• W2139798412 creator A5010806216 @default.
• W2139798412 creator A5017354451 @default.
• W2139798412 creator A5043458822 @default.
• W2139798412 creator A5063329234 @default.
• W2139798412 creator A5066848145 @default.
• W2139798412 date "2010-03-21" @default.
• W2139798412 modified "2023-09-25" @default.
• W2139798412 title "Monitoring neural activity with bioluminescence during natural behavior" @default.
• W2139798412 cites W1508316654 @default.
• W2139798412 cites W1672764189 @default.
• W2139798412 cites W1750683838 @default.
• W2139798412 cites W1972101224 @default.
• W2139798412 cites W1979457930 @default.
• W2139798412 cites W1979606683 @default.
• W2139798412 cites W1981782196 @default.
• W2139798412 cites W1983308977 @default.
• W2139798412 cites W1983659533 @default.
• W2139798412 cites W1992346348 @default.
• W2139798412 cites W1993608624 @default.
• W2139798412 cites W1996214950 @default.
• W2139798412 cites W1999055090 @default.
• W2139798412 cites W2001341743 @default.
• W2139798412 cites W2011896135 @default.
• W2139798412 cites W2032389394 @default.
• W2139798412 cites W2033708119 @default.
• W2139798412 cites W2037200881 @default.
• W2139798412 cites W2037594700 @default.
• W2139798412 cites W2038757483 @default.
• W2139798412 cites W2041321444 @default.
• W2139798412 cites W2043274097 @default.
• W2139798412 cites W2045079350 @default.
• W2139798412 cites W2054316680 @default.
• W2139798412 cites W2056908467 @default.
• W2139798412 cites W2058513643 @default.
• W2139798412 cites W2063210874 @default.
• W2139798412 cites W2068927073 @default.
• W2139798412 cites W2068958126 @default.
• W2139798412 cites W2072154498 @default.
• W2139798412 cites W2072328648 @default.
• W2139798412 cites W2074425528 @default.
• W2139798412 cites W2074967846 @default.
• W2139798412 cites W2085712847 @default.
• W2139798412 cites W2099791270 @default.
• W2139798412 cites W2100743305 @default.
• W2139798412 cites W2101781927 @default.
• W2139798412 cites W2112938540 @default.
• W2139798412 cites W2117723173 @default.
• W2139798412 cites W2126672460 @default.
• W2139798412 cites W2129357751 @default.
• W2139798412 cites W2131014580 @default.
• W2139798412 cites W2133507210 @default.
• W2139798412 cites W2133844804 @default.
• W2139798412 cites W2138698653 @default.
• W2139798412 cites W2147955244 @default.
• W2139798412 cites W2169378022 @default.
• W2139798412 cites W2181366372 @default.
• W2139798412 cites W610058166 @default.
• W2139798412 doi "https://doi.org/10.1038/nn.2518" @default.
• W2139798412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2846983" @default.
• W2139798412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20305645" @default.
• W2139798412 hasPublicationYear "2010" @default.
• W2139798412 type Work @default.
• W2139798412 sameAs 2139798412 @default.
• W2139798412 citedByCount "176" @default.
• W2139798412 countsByYear W21397984122012 @default.
• W2139798412 countsByYear W21397984122013 @default.
• W2139798412 countsByYear W21397984122014 @default.
• W2139798412 countsByYear W21397984122015 @default.
• W2139798412 countsByYear W21397984122016 @default.
• W2139798412 countsByYear W21397984122017 @default.
• W2139798412 countsByYear W21397984122018 @default.
• W2139798412 countsByYear W21397984122019 @default.
• W2139798412 countsByYear W21397984122020 @default.
• W2139798412 countsByYear W21397984122021 @default.
• W2139798412 countsByYear W21397984122022 @default.
• W2139798412 countsByYear W21397984122023 @default.
• W2139798412 crossrefType "journal-article" @default.
• W2139798412 hasAuthorship W2139798412A5010806216 @default.
• W2139798412 hasAuthorship W2139798412A5017354451 @default.
• W2139798412 hasAuthorship W2139798412A5043458822 @default.
• W2139798412 hasAuthorship W2139798412A5063329234 @default.
• W2139798412 hasAuthorship W2139798412A5066848145 @default.
• W2139798412 hasBestOaLocation W21397984122 @default.
• W2139798412 hasConcept C104317684 @default.
• W2139798412 hasConcept C118403218 @default.
• W2139798412 hasConcept C142613039 @default.
• W2139798412 hasConcept C169760540 @default.
• W2139798412 hasConcept C17189327 @default.
• W2139798412 hasConcept C2776878037 @default.
• W2139798412 hasConcept C2908647359 @default.
• W2139798412 hasConcept C2984127161 @default.
• W2139798412 hasConcept C50738837 @default.
• W2139798412 hasConcept C5176359 @default.
• W2139798412 hasConcept C55493867 @default.
• W2139798412 hasConcept C71924100 @default.
• W2139798412 hasConcept C74254510 @default.

• next