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• W2139808976 abstract "Vitis thunbergii is used in Taiwan as a botanical supplement for inflammatory bone diseases. This study aims to examine its direct effect on bone metabolism. Three-month-old female mice were randomly divided into ovariectomized control (OVX), sham operated (SHAM), and ovariectomy treated with either 17 β -estradiol or a special ingredient (VtR) fractionated from an ethanol extract of V. thunbergii started two weeks after ovariectomy. VtR treatment for 8 weeks significantly ameliorated the deterioration of bone mineral density and reversed all the ovariectomy-induced changes in μ -CT parameters. The antiosteoporotic effect of VtR accompanied decrease in serum levels of C-terminal telopeptides of type I collagen (CTx), interleukin-7, and ration of RANKL/osteoprotegerin (OPG) but rise in osteocalcin concentration. Sparse calcified microarchitecture and less alkaline-phosphatase- (ALP-) positive cells were observed at the femur and vertebral sites in OVX mice while VtR remarkably restored such variation. HPLC analysis showed (+)-vitisin-A, (−)-vitisin-B, and ampelopsin C predominated in VtR. Both (−)-vitisin B and ampelopsin C increased ALP activity and bone nodule formation in cultured osteoblasts. Instead of stimulating osteoblastogenesis, (+)-vitisin A dramatically repressed osteoclasts differentiation and bone resorption. The results suggested VtR composed of diverse components to reciprocally drive osteoblastogenesis and interdict osteoclastogenesis may serve as a potential botanic drug for osteoporosis therapy." @default.
• W2139808976 created "2016-06-24" @default.
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• W2139808976 date "2013-01-01" @default.
• W2139808976 modified "2023-10-15" @default.
• W2139808976 title "A Special Ingredient (VtR) Containing Oligostilbenes Isolated from<i>Vitis thunbergii</i>Prevents Bone Loss in Ovariectomized Mice:<i>In Vitro</i>and<i>In Vivo</i>Study" @default.
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• W2139808976 doi "https://doi.org/10.1155/2013/409421" @default.
• W2139808976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3638587" @default.
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