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- W2139816602 abstract "The authors describe a method for biomolecular force clamp measurements using atomic force microscope (AFM) cantilevers and micromachined membrane-based electrostatic actuators. The actuators comprise of Parylene membranes with embedded side actuation electrodes and are fabricated on a silicon substrate. The devices have a displacement range of 1.8 μm with 200 V actuation voltage, and displacement uncertainty is 0.8 nm, including the noise and drift. The settling time, limited by the particular amplifier is 5 ms, with an inherent range down to 20 μs. A force clamp measurement setup using these actuators in a feedback loop has been used to measure bond life-times between human IgG and anti-human IgG molecules to demonstrate the feasibility of this method for biological experiments. The experimental findings are compared with a molecular pulling experiment and the results are found to be in good agreement." @default.
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- W2139816602 date "2012-11-01" @default.
- W2139816602 modified "2023-09-23" @default.
- W2139816602 title "Atomic force microscope based biomolecular force-clamp measurements using a micromachined electrostatic actuator" @default.
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- W2139816602 doi "https://doi.org/10.1016/j.ultramic.2012.07.023" @default.
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